The goal of Dr. Subramanya’s research is to define and understand new molecular pathways that coordinate sodium, chloride, and potassium transport in the kidney and other organs. His work has provided insights into the pathogenesis of renal salt wasting nephropathies, and identified novel mechanisms involved in the regulation of cell volume, blood pressure, and potassium balance.
- BS, University of Michigan, 1993
- MD, Case Western Reserve University, 1998
- Residency, Oregon Health and Science University, 2001
- Fellowship, Nephrology, Oregon Health and Science University, 2005
- AHA Postdoctoral Fellowship, Oregon Health and Science University, 2005
- NIH Postdoctoral Fellowship, University of Maryland, 2007
Education & Training
Boyd-Shiwarski CR, Beacham RT, Lashway JA, Querry KE, Griffiths SE, Shiwarski DJ, Knoell SA, Nguyen NH, Nkashama LJ, Valladares MN, Bandaru A, Marciszyn AL, Franks J, Sullivan M, Watkins SC, Rodan AR, Huang CL, Stocker SD, Kashlan OB, Subramanya AR. Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates. J Clin Invest. 2025 Jun 10;135(15):e188792. Doi: 10.1172/JCI188792. eCollection 2025 Aug 1. PMID: 40493421.
Boyd-Shiwarski CR, Shiwarski DJ, Subramanya AR. A new phase for WNK kinase signaling complexes as biomolecular condensates. Physiology. 2024 Sep 1;39(5):0. doi:10.1152/physiol.00013.2024. Epub 2024 Apr 16. PMID: 38624245.
Subramanya AR**, Boyd-Shiwarski CR. Molecular Crowding: Physiologic Sensing and Control. Ann Rev Physiol 2024 Feb 12:86:429-452. doi: 10.1146/annurev-physiol-042222-025920. Epub 2023 Nov 6. PMID 37931170.
Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Cell 2022 Nov 23; 185(24):4488-4506. Epub Oct 25. PMID: 36318922.
