Primary research focus is understanding the mechanisms underlying intestinal barrier disfunction and mucosal healing in inflammatory bowel diseases (IBD), in particular the translatability of animal models of disease to human. Currently collaborating with the Magee Women’s Research Institute, University of Pittsburgh and members of the pharmaceutical industry to support translational approaches to understanding target engagement and efficacy of new medical entities developed for the treatment of Crohn's disease and ulcerative colitis.
- BSc, University of Calgary
- PhD, University of Calgary, 1995
- Post Doctoral Fellowship, Queens University, Kingston, Ontario, 2000
Education & Training
Manthey, C.L. (co-first author), Moore, B.A. (co-first author), Chen, Y, Loza, M.J., Belkowski, S.M., Raymond-Parks, H., Dunford, P.J., Leon, F., Towne, J.E., Plevy, S.E. The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis. PLOS One. 2019; 14(11): e0223918.
Moore, B.A. Invited Editorial:Preventing postoperative ileus with n-3 PUFA. Journal of Leukocyte Biology. 2016; 99(2): 225.
Hornby, P.J. (co-first author), Moore, B.A. (co-first author). Invited Review:The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease. Expert Opinion Therapeutic Targets. 2011; 15(5): 637.
Shen, F., Volk, A., Jones, B., Coleman, B.M., Loza, M.J., Malaviya, R., Moore, B.A., Elloso, M., Gaffen, S.L., Ort, T. Combined Blockade of TNFa and IL-17A Ameliorates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice. Journal of Immunology. 2019; 202(7): 2017.
Valenzano, M.C., DiGuilio, K., Mercado, J., Teter, M., To, J., Ferraro, B., Mixson, B., Manley, I., Baker, V., Moore, B.A., Wertheimer, J., Mullin, J.M. Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients. PLOS One. 2015; 10(7): e013392.
Wade, P., Palmer, J., McKenney, S., Chevalier, K., Moore, B., Mabus, J., Saunders, P., Wallace, N., Schneider, C., Kimball, E., Breslin, H., He, W., Hornby, P. Modulation of gastrointestinal function by MuDelta, a mixed ? opioid receptor agonist/? opioid receptor antagonist. British Journal of Pharmacology. 2012; 167(5): 1111.
Moore, B.A., Manthey, C.L., Johnson, D.L., Bauer, A.J. Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Post-Operative Ileus. Gastroenterology. 2011; 141(4): 1283.
- Member, American Gastroenterological Assocation, 1991-present
- Samuel and Emma Winters Foundation, Biomedical Research, 2003
- Janssen Excellence in Leadership Award, Contributions to the Development Strategy in IBD, 2012
- Ad Hoc Reviewer, British Journal of Pharmacology, 2016
- Ad Hoc Reviewer, Critical Care Medicine, 2017
- Ad Hoc Reviewer, Journal of Pharmacology & Experimental Therapeutics, 2018
