Dr. Kaufman's long-standing research interest is to understand the contribution of mtDNA metabolism to disease progression. For 20 years he has been uncovering the fundamental processes that underlie mitochondrial respiratory deficiency with a focus on mtDNA stability and copy number control – processes essential for respiratory function and viability. Dr. Kaufman's major research goals are 1) to define the biochemical events responsible for the maintenance of mtDNA content, 2) to understand how distinct pathways influence mtDNA maintenance, and 3) to understand mechanisms of mtDNA damage and resistance to damage in the context of disease.
- BS, Biochemistry, Indiana University, 1995
- PhD, University of Texas Southwestern Medical Center at Dallas, 2003
- Postdoc, McGill University, 2008
Education & Training
Kaufman, BA, Picard, M, Sondheimer, N. Mitochondrial DNA, nuclear context, and the risk of carcinogenesis. Environmental and Molecular Mutagenesis. 2018
Falabella, M, Fernandez, RJ, Johnson, B, Kaufman, BA. Potential roles for G-quadruplexes in mitochondria. Current Medicinal Chemistry. 2018; epub ahead of print
Guha, M, Srinivasan, S, Roman, P, Jiang, Y, Kaufman, BA, Taylor, D, Dong, D, Chakrabarti, R, Picard, M, Carstens, RP, Kijima, Y, Feldman, M, Avadhani NG. Aggressive triple negative breast cancer have unique molecular signature on the basis of mitochondrial genetic and functional defects. Biochimica et Biophysica Acta. 2018; 1864(4 Pt A): 1060-1071.
Han HS, Dieras V, Robson M, Palacova M, Marcom PK, Jager A, Bondarenko I, Citrin D, Campone M,, Telli M, Domchek SM, Friedlander M, Kaufman B, Garber JE, Shparyk Y, Chmielowska E, Jakobsen EH, Kaklamani V, Grandishar W, Ratajczak CK. Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRA 1/2 locally recurrent/metastatic breast cancer: randomized phase II study. Annals of Oncology. 2018; 29(1): 154-161.
Falabella M, Sun L, Barr J, Pena AZ, Kershaw EE, Gingras S, Goncharova EA, Kaufman BA. Single-step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Edition Events in vivo G3. in vivo. 2017; 7(10): 3533-3542.
Guhha M, Srinivasan S, Guja K, Mejia E, Garcia-Diaz M, Johnson FB, Ruthel G, Kaufman BA, Rappaport EF, Glineburg MR, Fang JK, Szanto AK, Nakagawa H, Basha J, Kundu T, AVadhani NG. HnRPNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression. Cell Discovery. 2016; 2: 16045.
Isakoff SJ, Puhall S, Domchek SM, Friedlander M, Kaufman B, Robson M, Telli ML, Dieras V, Han HS, Garvber JE, Johnson EF, Maag D, Qin Q, Giranda VL, Shepherd SP. A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplantin/paclitaxel in BRCA 1/2 metastatic breast cancer: design and ratinale. Future Oncology. 2017; 13(4): 307-320.
Belmonte FR, Martin JL, Frescura K, Damas J, Pereira F, Tarnopolsky MA, Kaufman BA. Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions. Scientific Reports. 2016; 6: 25186.
- Phi Eta Sigma and Alpha Lambda Delta at Indiana University, 1992
- Harry G. Day Award for Chemistry, Indiana University, 1994
- Honors Division Grant, Indiana University, 1995
- Jeanne Timmons-Costello Postdoctoral Fellowship, 2003-2004
- Dr. David Lin Postdoctoral Fellowship, 2004-2005
- Canadian Institutes of Health Research/Muscular Dystrophy Association of Canada Postdoctoral Fellowship, 2005-2008
- Muscular Dystrophy Association Development Award, 2008-2010
- McCabe Fellow, 2009
- United Mitochondrial Disease Foundation Chairman's Proze for highest rated research grant, 2011
- Selected for the University of Pittsburgh Senior Vice Chancellor's Seminar Series, 2018
