Dr. Clancy's laboratories are interested in the molecular pathogenesis of invasive infections caused by the fungus Candida albicans.
Dr. Clancy's labs have implicated several novel genes in both organisms that contribute to the pathogenesis of candidiasis and aspergillosis. Biological processes related to these genes that are studied in the lab include histone methylation and transcriptional regulation, DNA damage responses, and phosphoinositide regulation.
In addition, he and Dr. Nguyen collaborate on research about mechanisms of antimicrobial resistance in bacteria and fungi and their clinical relevance.
- BA, Natural Sciences, The Johns Hopkins University, 1984
- MD, Washington University School of Medicine, 1991
- Residency, Internal Medicine, The Union Memorial Hospital, 1994
- Chief Resident, Internal Medicine, The Union Memorial Hospital, 1995
- Fellowship, Infectious Diseases, University of Florida, 2000
Education & Training
Fleres G, Cheng S, Badrane H, Dupont CL, Espinoza JL, Abbey D, Driscoll E, Newbrough A, Hao B, Mansour A, Nguyen MH, Clancy CJ. Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness. J Infect Dis. 2026 Mar 17;233(3):560-572. PMID: 41026105.
Tamma PD, Aitken SL, Bonomo RA, Mathers AJ, van Duin D, Clancy CJ. Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections. Clin Infect Dis. 2023 Jul 18:ciad428. PMID: 37463564.
Buehrle DJ, Decker BK, Wagener MM, Adalja A, Singh N, McEllistrem MC, Nguyen MH, Clancy CJ. Antibiotic Consumption and Stewardship at a Hospital outside of an Early Coronavirus Disease 2019 Epicenter. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01011-20. PMID: 32816693.
Shields RK, Kline EG, Healey KR, Kordalewska M, Perlin DS, Nguyen MH, Clancy CJ. Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e01692-18. PMID: 30373796.
Decker BK, Harris PL, Muder RR, Hong JH, Singh N, Sonel AF, Clancy CJ. Improving the Diagnosis of Legionella Pneumonia within a Healthcare System through a Systematic Consultation and Testing Program. Ann Am Thorac Soc. 2016 Aug;13(8):1289-93. PMID: 27243279.
