Dr. Clancy's laboratories are interested in the molecular pathogenesis of invasive infections caused by the fungus Candida albicans.
Dr. Clancy's labs have implicated several novel genes in both organisms that contribute to the pathogenesis of candidiasis and aspergillosis. Biological processes related to these genes that are studied in the lab include histone methylation and transcriptional regulation, DNA damage responses, and phosphoinositide regulation.
In addition, he and Dr. Nguyen collaborate on research about mechanisms of antimicrobial resistance in bacteria and fungi and their clinical relevance.
- BA, Natural Sciences, The Johns Hopkins University, 1984
- MD, Washington University School of Medicine, 1991
- Residency, Internal Medicine, The Union Memorial Hospital, 1994
- Chief Resident, Internal Medicine, The Union Memorial Hospital, 1995
- Fellowship, Infectious Diseases, University of Florida, 2000
Education & Training
Raman, SB, Nguyen, MH, Cheng, S, Badrane, H, Iczkowski, KA, Wegener, M, Gaffen, SL, Mitchell, AP, Clancy, CJ. A competitive infection model of hematogenously disseminated candidiasis in mice redefines the role of Candida albicans IRS4 in pathogenesis. Infection and Immunity. 2013; 81(5): 1430-8.
Badrane, H, Nguyen, MH, Clancy, CJ. Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans. Antimicrobial Agents and Chemotherapy. 2016; 60(6): 3591-600.
Shields, RK, Nguyen, MH, Press, EG, Cumbie, R, Driscoll, E, Pasculle, AW, Clancy, CJ. Rate of FKS Mutations among Consecutive Candida Isolates Causing Bloodstream Infection. Antimicrobial Agents and Chemotherapy. 2015; 59(12): 7465-70.
Clancy, CJ, Meslin, C, Badrane, H, Cheng, S, Losada, LC,, Nieman, WC, Vergidis, P, Clark, NL, Nguyen, MH. Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage Open Forum. Infectious Diseases. 2016; 3(3): doi:10.1093/ofid/ofw120.
Shankar, J, Nguyen, MH, Crespo, MM, Kwak, EJ, Lucas, SK, McHugh, KH, Mounaud, S, Alcorn, JF, Pilewski, JM, Shigemura, N, Kolls, JK, Nieman, WC, Clancy, CJ. Looking Beyond Respiratory Cultures: Microbiome-Cytokine Signatures of Bacterial Pneumonia and Tracheobronchitis in Lung Transplant Recipients. American Journal of Transplantation. 2016; 16(6): 1766-78.
