Our laboratory is interested in identifying new molecular pathways in epithelial biology in the pathogenesis of tissue remodeling in chronic obstructive lung disease (COPD) and pulmonary fibrosis to improve therapeutic options for patients. Our lab specifically studies the role of adenine nucleotide translocase (a canonical mitochondrial ADP/ATP transporter) in the airway and alveolar epithelium of the lung in the context of cigarette smoking-related lung disease and lung fibrosis. We want to better understand how in health and disease ANT regulates epithelial function through cell metabolism and cellular senescence, as well as, airway epithelial homeostasis through surface hydration and the action of tiny motile cilia in the airway. We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine epithelial cell homeostasis in the lung.
Dr. Kliment's clinical specialty is in the care of patients with acute and chronic respiratory failure and critical illness. Her clinical service is focused in the Medical Intensive Care Unit at Presbyterian Hospital, focused on the care of critically ill patients and their families. She also attends on the Pulmonary consultation and Advanced Lung Disease services.
Dr. Kliment is actively involved in the teaching and mentoring of medical students, MD/PhD students, graduate students, residents and fellows in Pulmonary and Critical Care Medicine. She is interested in training the next generation of physician-scientists interested in the cellular and molecular pathology of the lung.
- BS, Biochemistry, University of Nebraska, 2004
- PhD, Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, 2009
- MD, MSTP, University of Pittsburgh School of Medicine, 2011
- Residency, Internal Medicine, Brigham and Women's Hospital, Harvard, 2014
- Fellowship, Pulmonary and Critical Care, Johns Hopkins Hospital, 2018
Education & Training
Kliment CR, Araki T, Doyle TJ, Gao W, Dupuis J, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Estepar RS, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O'Connor GT, Hatabu H. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulmonary Medicine. 2015; 15: 134.
Gregory AD, Kliment CR, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. Journal of Leukocyte Biology. 2015; 98(2): 143-52.
Kliment CR, Englert JM, Cru LP, Oury TD. A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. International Journal of Clinical and Experimental Pathology. 2011; 4(4): 349-5.
Kliment CR, Oury TD. Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding. Free Radical Biology & Medicine. 2011; 50(9): 1075-80.
Kliment CR, Oury TD. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radical Biology & Medicine. 2010; 49(5): 707-17.
Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature Medicine. 2010; 16(2): 219-23.
Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. JBC. 2009; 284(6): 3537-45.
Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, Day BJ, Zhu X, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. Extracellular superoxide dismutase regulates cardiac function and fibrosis. Journal of Molecular and Cellular Cardiology. 2009; 47(5): 730-42.
Myllarniemi M, Lindholm P, Ryynanen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K. Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 2008; 177(3): 321-9.
Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxidants & Redox Signaling. 2008; 10(2): 261-8.
- Young Investigators Respiratory Research Forum 2015, 2015
- American Society of Cell Biology “Best Cell Stories of 2015” Abstract Honors Pick, 2015
- Johns Hopkins Baurenschmidt Research Fellowship, 2015
- National Research Service Award (NRSA) F32 Individual Postdoctoral Fellowship - NHLBI, 2016
- Johns Hopkins Pulmonary Medicine COPD Pilot Award, 2016
- Johns Hopkins Young Investigators Day -Physician Scientist Award, 2018
- Pittsburgh International Lung Conference, Outstanding Scientific Research Award, 2018
- Parker B. Francis Fellowship, 2018
- NIH K08 Early Career Mentored Research Award - National Heart, Lung and Blood Institute, 2018
- Burroughs Wellcome Fund Career Award for Medical Scientists, 2018
