The St. Hilaire lab research program stems from the previous discovery of the genetic disease Arterial Calcification due to Deficiency of CD73 (ACDC), which identified a novel role for the enzyme CD73, and its substrate adenosine, in vascular calcification and vascular remodeling. Moving forward research in the St. Hilaire lab will explore the role of CD73 and adenosine signaling in more complex vascular pathologies such as atherosclerosis, calcific aortic valve disease, and aneurysms using in vitro (primary human and mouse cells and patient-specific induced-pluripotent stem cells) and in vivo (genetically defined murine models and surgical manipulations), with the goal of translating findings in ACDC to more common vascular diseases and pathologies.
- PhD, Boston University School of Medicine, 2008
- Postdoctoral Fellowship, Vascular Biology, National Heart, Lung, and Blood Institute, 2015
Education & Training
St Hilaire C, Ziegler SG, Markello TC, Brusco A, Geoden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen NMY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudental B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum FL, Kleta R, Gahl WA, Boehm M. NT5E mutations and arterial calcifications. N Engl J Med PubMed PMID: 21288095; PubMed Central PMCID: PMC3049958. 2011; 364(5): 432-42.
Markello TC, Pak LK, St Hilaire C, Dorward H, Ziegler SG, Chen MY, Chaganti K, Nussbaum FL, Boehm M, Gahl WA. Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab. 2011; 103 - May 2011: 44-50.
Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. TGF-ß signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med. 2014; 6(227) - Mar 12 2014: PubMedPMID:24622514_PubMedCentralPMCID:PMC41.
Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014; 371(6): 507-18.
Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller C, St Hilaire C, Shanahan. Medial vascular calcification revisited: review and perspectives. Eur Heart J. 2014; 35(23): 1515-1525.
Boehm M, St Hilaire C. Vascular Genetics. PanVascular Medicine, 2nd ed. Lanzer P. (Ed.) Springer Heidelberg New York. 2015; DOI: 10.1007/978-3-642-37393-0_4-1: 53-88.
Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St. Hilaire C, Boehm M. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. Journal of Clinical Investigations. 2010; 120(1): 303-14.
Nguyen HG, Makitalo M, Yang D, Chinnappan D, St. Hilaire C, Ravid K. Deregulated Auroa-B induced tetraploidy promotes tumorigenesis. Federation of American Societies for Experimental Biology Journal. 2009; 23(8): 2741-8.
- Henry I. Russek Student Achievement Day, 2008
- 8th Annual NHLBI Division of Intramural Research, 2010
- NHLBI Star Awards, Excellence in Laboratory Basic and Clinical, 2010
- Fellows Award for Research Excellence, 2011
- Outstanding Poster Award, 2011
- Best Peripheral Artery Disease Research Award, 2011
- Orloff Science Award for Outstanding Scientific Contributions, 2012
- NHLBI Director’s Award – Outstanding Translational Science, 2013
- Orloff Science Award, 2015
