Dr. David Binion is a Professor of Medicine and inflammatory bowel disease (IBD) investigator whose career has focused on defining the cellular and molecular mechanisms underlying human chronic gut inflammation and the translation of this knowledge into improved care for patients suffering from Crohn’s disease and ulcerative colitis. Current work has centered on Big Data analytics and the development and transformation of the UPMC IBD Registry, a prospective, multi-year, longitudinal natural history registry database of >3,000 consented IBD patients into a metadata platform for scientific discovery. Working in collaboration with computer scientists from the University of Pittsburgh School of Information Science, this relational database continuously curates and transforms observational clinical information from the electronic medical record (EMR) and maintains >10,000 person-years of associated metadata in a secure data warehouse. Areas of active investigation include:
• Developing prognostic biomarkers of IBD severity.
• Characterizing the impact of diet and nutrition on IBD natural history.
• Identification of biomarker patterns to predict development of dysplasia/cancer in IBD.
• Identification of predictive biomarkers to guide therapeutic selection in IBD.
• Comparative effectiveness studies in IBD maintenance therapy.
• Defining the impact of surgical anastomotic technique on longterm clinical outcomes in Crohn’s disease.
• Use of healthcare charge data as a comprehensive phenotype.
• Defining the impact of Clostridium difficile infection on IBD natural history.
• Characterizing extra-intestinal manifestations including anemia and autonomic dysfunction on the natural history of IBD.
• Developing clinical decision support tools to optimize IBD care and implement precision medicine.
- AB, General Studies, Harvard College, 1984
- MD, State University of New York at Buffalo, 1988
- Residency, Rhode Island Hospital (Brown University), 1991
- Fellowship, Gastroenterology, University Hospitals of Cleveland (Case Western), 1993
- Research Fellow, Immunology, Cleveland Clinic Foundation Research Institute, 1993
Education & Training
Regueiro, M., Kip, K.E., Schraut, W., Baidoo, L., Sepulveda, A.R., Pesci, M., El-Hachem, S., Harrison, J., Binion, D. Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection. Inflammatory Bowel Diseases. 2011; 17(1): 118-26.
Barrie, A., Mourabet, M.E., Weyant, K., Clarke, K., Gajendran, M., Rivers, C., Park, S.Y., Hartman, D., Saul, M., Regueiro, M., Yadav, D., Binion, D.G. Recurrent blood eosinophilia in ulcerative colitis is associated with severe disease and primary sclerosing cholangitis. Digestive Diseases and Sciences. 2013; 58(1): 222-8.
Ramos-Rivers, C., Regueiro, M., Vargas, E.J., Szigethy, E., Schoen, R.E., Dunn, M., Watson, A.R., Schwartz, M., Swoger, J., Baidoo, L., Barrie, A., Dudekula, A., Youk, A.O., Binion, D.G. Association between telephone activity and features of patients with inflammatory bowel disease. Clinical Gastroenterology and Hepatology. 2014; 12(6): 986-94.
Koutroubakis, I.E., Regueiro, M., Schoen, R.E., Ramos-Rivers, C., Hashash, J.G., Schwartz, M., Swoger, J., Barrie, A., Baidoo, L., Dunn, M.A., Hartman, D., Binion, D.G. Multiyear Patterns of Serum Inflammatory Biomarkers and Risk of Colorectal Neoplasia in Patients with Ulcerative Colitis. Inflammatory Bowel Diseases. 2016; 22(1): 100-5.
Bhagya Rao, B., Koutroubakis, I.E., Ramos Rivers, C., Colombel, J.F., Regueiro, M., Swoger, J., Schwartz, M., Baidoo, L., Hashash, J., Barrie, A., Dunn, M.A., Binion, D.G. Delineation of Crohn's Disease Trajectories Using Change in Lemann Index: A Natural History Study. Journal of Clinical Gastroenterology. 2016; 50(6): 476-82.
Kabbani, T.A., Koutroubakis, I.E., Schoen, R.E., Ramos-Rivers, C., Shah, N., Swoger, J., Regueiro, M., Barrie, A., Schwartz, M., Hashash, J.G., Baidoo, L., Dunn, M.A., Binion, D.G. Association of Vitamin D Level with Clinical Status in Inflammatory Bowel Disease: A 5-Year Longitudinal Study. The American Journal of Gastroenterology. 2016; 111(5): 712-9.
Jiang, J., Click, B., Anderson, A.M., Koutroubakis, I.E., Rivers, C.R., Hashash, J.G., Dunn, M.A., Schwartz, M., Swoger, J., Barrie, A., Regueiro, M., Chang, C.C., Binion, D.G. Group-based Trajectory Modeling of Healthcare Financial Charges in Inflammatory Bowel Disease: A Comprehensive Phenotype. Clinical and Translational Gastroenterology. 2016; 7(7): e181.
- Fellow, American Gastroenterological Association, 2007
- Sherman Prize Recipient, 2018
- Pittsburgh Best Doctors 2021-22 (Pittsburgh Magazine & Castle Connolly), 2022
- Excellence in Healthcare Honoree - WPA/WV Chapter, Crohn's & Colitis Foundation, 2022
