My laboratory studies immunoregulation and tolerance in allograft and autoimmune models. We have used reagents that and promote tolerance by targeting specific molecules. By studying their basic mechanism(s) of action we can identify new immunoregulatory pathways.
- BA, University at Buffalo
- MD, The University of Pennsylvania School of Medicine
- Residency, Hospital of the University of Pennsylvania
- Fellowship, Brigham & Women's Hospital - Harvard Medical School
Education & Training
Li, H., Demetris, A.J., McNiff, J., Matte-Martone, C., Tan, H.S., Rothstein, D.M., Lakkis, F.G., Shlomchik, W.D. Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. Journal of Immunology. 2012; 188(8): 3804-11.
Walch, J.M., Zeng, Q., Li,Q., Oberbarnscheidt, M.H., Hoffman, R.A., Williams, A.L., Rothstein, D.M., Schlomchik, W.D., Kim, J.V., Camirand, G., Lakkis, F.G. Cognate antigen directs CD8+ T cell migration to vascularized transplants. Journal of Clinical Investigation. 2013; 123(6): 2663-71.
Cherukirr, A., Rothstein, D.M., Clark, B., Carter, C.R., Davidson, A., Hernandez, Fuentes, M., Hewitt, E., Salama, A.D., Baker, R.J. Immunologic human renal allograft injury associates with an altered IL-10/TNF-a expression ratio in regulatory B cells. Journal of the American Society of Nephrology. 2014; 25(7): 1575-85.
Vergani, A., Gatti, F., Lee, K.M., D'Addio, F., Tezza, S., Chin, M., Bassi, R., Tian, Z., Wu, E., Maffi, P., Ben Nasr, M., Kim, J.I., Secchi, A., Markmann, J.F., Rothstein, D.M., Turka, L.A., Sayegh, M.H., Fiorina, P. TIM4 Regulates the Anti-Islet Th2 Alloimmune Response. Cell Transplant. 2015; 24(8): 1599-614.
Oberbarnscheidt, M.H., Zeng, Q., Li, Q., Dai, H., Williams, A.L., Shlomchik, W.D., Rothstein, M.D., Lakkis, F.G. Non-self recognition by monocytes initiates allograft rejection. Journal of Clinical Investigation. 2014; 124(8): 3579-89.
Camirand, G., Wang, Y., Lu, Y., Wan, Y.Y., Lin, Y., Deng, S., Guz, G., Perkins, D.L., Finn, P.W., Farber, D.L., Flavell, R.A., Sclomchik, W.D., Lakkis, F.G., Rudd, C.E., Rothstein, D.M. CD45 ligation expands Tregs by promoting interactions with DCs. Journal Clinical Investigation. 2014; 124(10): 4603-13.
Kim, J.I., Rothstein, D.M., Markmann, J.F. Role of B cells in tolerance induction. Current Opinion in Organ Transplantation. 2015; 20(4): 369-75.
Rothstein, D.M., Camirand, G. New insights into the mechanisms of Treg function. Current Opinion in Organ Transplantation. 2015; 20(4): 376-84.
Grossman, T.H., Starosta, A.L., Fyfe, C., O;Brien, W., Rothstein, D.M., Mikolajka, A., Wilson, D.N., Sutcliffe, J.A. Erratum for Grossman et al., target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrobial Agents and Chemotherapy. 2015; 59(9): 5870.
Rothstein, D.M. Rifamycins, Alone and in Combination. Cold Spring Harbor Perspectives in Medicine. 2016; 6(7): a027011.
