Dr. Chandra’s research focuses on three aspects of COPD:
How does a disease of the lung (COPD) produce varied systemic comorbidities such as atherosclerosis and kidney dysfunction? This research uses a translational approach, and focuses on the study of inflammatory and autoimmunity processes as novel mechanisms for systemic vascular injury in COPD.
Are there as yet undefined systemic manifestations of COPD and how can these be identified? This work includes the first description of a novel emphysema kidney injury phenotype.
How can phenomic data on patients with COPD be analyzed and interpreted using advanced computational methods to understand disease heterogeneity?
Dr. Chandra’s clinical interests focus on critical illness and chronic obstructive pulmonary disease (COPD). In COPD, he is specifically interested in systemic manifestations of this disease including atherosclerosis. He is board certified in Internal Medicine, Pulmonary Disease, and Critical Care Medicine.
- MD, All India Institute of Medical Sciences, 2003
- MSc, Clinical Epidemiology, Harvard School of Public Health, 2008
- Residency, Internal Medicine, Baylor College of Medicine, 2007
- Fellowship, Pulmonary, Allergy & Critical Care Medicine, University of Pittsburgh School of Medicine, 2012
Education & Training
Bon J, Zhang Y, Leader JK, Fuhrman C, Perera S, Chandra D, Bertolet M, Diergaarde B, Greenspan SL, Sciurba FC. Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc. 2018; May;14(5): 615-621.
Chandra D, Palevsky P, Sciurba FC. EnRAGEed Kidneys in Chronic Obstructive Pulmonary Disease?. Am J Respir Crit Care Med. 2017; Jun 1;195(11): 1411-1413.
Chandra D, Gupta A, Leader JK, Fitzpatrick M, Kingsley LA, Kleerup E, Haberlen SA, Budoff MJ, Witt M, Post WS, Sciurba FC, Morris A. Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study. PLoS One. 2017; Apr 28;12: 4.
Chandra D, Gupta A, Strollo PJ Jr, Fuhrman CR, Leader JK, Bon J, Slivka WA, Shoushtari AH, Avolio J, Kip KE, Reis S, Sciurba FC. Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis. Am J Respir Crit Care Med. 2016; Jul 1;194(1): 38-47.
Sciurba FC, Chandra D, Bon J. Bronchoscopic Lung Volume Reduction in COPD:Lessons in Implementing Clinically Based Precision Medicine. JAMA. 2016; Jan 12;315(2): 139-41.
Bon J, Kahloon R, Zhang Y, Xue J, Fuhrman CR, Tan J, Burger M, Kass DJ, Cxizmadia E, Otterbein L, Chandra D, Bhargava A, Pilewski JM, Roodman GD, Sciurba FC, Duncan SR. Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers. PLoS One. 2014; Sep 12;9: 9.
Gupta S, Chandra D, Sciurba F. Minimal or maximal clinically important differences: Using death to define MCID. Am J Resp Crit Care Med. 2013; 187: 1391-1392.
Chandra D, Stamm J, Palevsk P, Leader J, Fuhrman C, Zhang Y, Bon J, Duncan S, Branch R, Weissfeld J, Gur D, Gladwin M, Sciurba FC. The relationship between pulmonary emphysema and kidney function in smokers. CHEST. 2012; 142: 655-662.
Chandra D, Wise RA, Kulkarni HS, Benzo RP, Criner G, Make B, Slivka WA, Ries AL, Reilly JJ, Martines FJ, Sciurba FC, for the NETT Research Group. Optimizing the six minute walk test as a measure of exercise capacity in COPD. CHEST. 2012; 142(6): 1545-52.
Chandra D, Sciurba FC, Gladwin MT. Endothelial chronic destructive pulmonary disease (E-CDPD): is endothelial apoptosis a subphenotype or prequel to COPD?. Am J Respir Crit Care Med. 2011; Jul 15:184(2): 153-5.
- National Merit Come Means Scholarship/National Prize, Government of India, 1997
- American Thoracic Society, RSF Research Abstract Excellence Award, 2009
- Bernie Pennock Outstanding Young Investigator Award, 2016
