Academic Interests
\Dr. Lechman's research interests are centered on normal and malignant human hematopoietic stem and progenitor cell biology. My current research is focused on (1) understanding non-coding RNA control of the molecular and signaling pathways that direct the cellular fate of normal and malignant human hematopoietic stem and progenitor cells and (2) elucidating the developmental, cellular and molecular origins of adult and pediatric leukemia. My research is guided by multi-omic analysis of primary patient samples/tissues and utilizes functional genomics in combination with xenotransplantation into immune deficient mice. It is his hope that this work will advance the prospects for the therapeutic targeting of LSC and pre-leukemic HSC.
- PhD, University of Pittsburgh School of Medicine, 2003
- Postdoctoral Fellow, Princess Margaret Cancer Center, Toronto, Ontario, Canada
- Affiliate Scientist, Princess Margaret Cancer Center, Toronto, Ontario, Canada
Education & Training
- David Rae Memorial Fellowship, LRFC, Canada, 2004-2005
- Berlex Research Award, 2005
- Keystone Symposia Scholarship, 2006
- ISSCR Junior Investigator Award, 2006
- Keystone Symposia Future of Science Fund Scholarship, 2011
- ISSCR Junior Investigator Award, 2011
- AACR Scholar in Training Award, 2012
- University Health Network Catalyst Grant, 2022-2023
- Stanley M. Marks Blood Cancer Research Fund Scholar Award, 2023
- LLS Canada Pediatric Blood Cancer Research Innovation Grant, 2022-2024
Honors and Awards
Publications
