Dr. Arteel’s research focuses on the interaction between hepatotoxicants (e.g., arsenic) and lifestyle choices (e.g., obesity and alcohol) in the initiation and progression of chronic liver diseases. His current research foci are based on the understanding that transitional changes to the ECM proteome (i.e., “matrisome”) play an underappreciated role in the initiation and progression of liver disease. He is developing computational tools to attempt to predict mechanism(s) and to develop biomarkers (or surrogate biomarkers) for use in the clinics.
Dr. Arteel has been an active teacher for medical, graduate and dental students. He is also an active mentor/advisor for graduate students and post-doctoral fellows, having served as the primary advisor for over 25 graduate students and post-docs, plus serving on over 25 graduate student committees.
- BS, University of Wisconsin-Madison, 1993
- PhD, University of North Carolina-Chapel Hill, 1997
- Postdoctoral Fellow, Heinrich-Heine University, Düsseldorf, Germany, 1998
- Postdoctoral Fellow, University of North Carolina-Chapel Hill, 2000
Education & Training
McKim SE, Gäbele E, Isayama F, Lambert JC, Tucker LM, Wheeler MD, Connor HD, Mason RP, Doll MA, Hein DW, Arteel GE. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology. 2003; 125: 1834-44.
Guo L, Richardson KS, Tucker LM, Doll MA, Hein DW, Arteel GE. Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats. Hepatology. 2004; 40: 583-89.
Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I, Luyendyk JP, Roth RA, Arteel GE. Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology. 2006; 130: 2099-112.
Beier JI, Luyendyk JP, Guo L, von Montfort C, Arteel GE. Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice. Hepatology. 2009; 49: 1545-53.
Beier JI, Jokinen JD, Holz GE, Whang PS, Martin AM, Warner NL, Arteel GE, Lukashevich IS. Novel Mechanism of Arenavirus-Induced Liver Pathology. PLoSOne. 2014; 10: e0122839.
Massey VL, Dolin CE, Poole LG, Hudson SV, Siow DL, Brock GN, Merchant ML, Wilkey DW, Arteel GE. The hepatic “matrisome” responds dynamically to injury: characterization of transitional changes to the extracellular matrix. Hepatology. 2017; 65: 969-82.
You, M., Arteel, G.E. Effect of ethanol on lipid metabolism. Journal of Hepatology. 2018; 70(2): 237-248.
Arteel, GE, Naba, A. The liver matrisome - looking beyond collagens. JHEP Reports. 2020; 2: 100115.
Sato T, Head KZ, Li J, Dolin CE, Wilkey D, Skirtich N, Smith K, McCreary DD, Liu S, Beier JI, Singhi AD, McEnaney RM, Merchant ML, Arteel GE. Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2. Matrix Biology Plus. 2022; 17: 100127.
- Fellow of the American Association for the Study of Liver Diseases (FAASLD), 2015
- Member and Chair, Basic Research Committee, American Association for the Study of Liver Diseases, 2015-2017
- Chair, Hepatobiliary and Pathophysiology (HBPP) study section, 2018-2020
- UW-Madison Pharm/Tox Program Alumnus of the Year, 2019
R01 DK130294, Novel Biomarkers for Post-Liver Transplant NASH Fibrosis, 2022-2026.
R01 AA028436, Biomarkers of Alcoholic Hepatitis, 2020-2026.
R01 AA030007, The role of matrix-bound microvesicles in alcohol-related liver disease, 2023-2028.
