Dr. Chalasani’s main interests include memory T cell biology, antibody-independent functions of B cells and pathogenesis of chronic rejection. Her laboratory is focused on understanding how memory T cells are generated in transplantation. Her group is investigating how B cell functions and their innate activation pathways contribute to T cell memory and chronic rejection, and how different B cell populations impact these processes. Other relevant translational areas of research include changes in B cell subpopulations and functions under depletional and non-depletional induction regimens in kidney transplant recipients; impact of circulating BAFF levels and concominant donor specific B and T cell memory in kidney transplant recipients undergoing early rejection; and immune exhaustion in pediatric liver transplant recipients as a mechanism of operational tolerance off immunosuppression.
- Pre-University, Karnataka Science College, India, 1989
- MBBS, Rajiv Gandhi University of Health Sciences, India, 1996
- Residency, Internal Medicine, Wayne State University, Detroit Medical Center, 2000
- Fellowship, Nephrology, Emory University School of Medicine, 2001
- Fellowship, Nephrology, Yale University School of Medicine, 2004
Education & Training
Hoffman W, Lakkis FG, Chalasani G. B Cells, Antibodies, and More. Clinical Journal of the American Society of Nephrology. 2016; 11 (1): 137-54.
Ramaswami B, Chalasani G. The end is in sight: targeting sensitization in hematopoietic cell transplantation. American Journal of Transplantation. 2015; 15(4): 857-8.
Zeng Q, Ng YH, Singh T, Jiang K, Sheriff KA, Ippolito R, Zahalka S, Li Q, Randhawa P, Hoffman RA, Ramaswami B\, Lund FE, Chalasani G. B cells mediate chronic allograft rejection independently of antibody production. Journal of Clinical Investigation. 2014; 124(3): 1052-6.
