My research is focused on fibroblast biology in Idiopathic Pulmonary Fibrosis (IPF) at the Simmons Center for ILD. Particularly, I am interested in mechanism of action of IL8-family chemokine ‘CXCL6’ and its receptors CXCR1/2 that underlie IPF. Other interests include the role of TWIST1 in IPF and the role of GDF15 in GFRAL-independent mechanisms in the injury of the lung and liver.
- BS, Chemistry, S.K. University, India, 1999
- MSc, University of Hyderabad, India, 2001
- PhD, Schmidt College of Medicine, Florida Atlantic University, 2010
Education & Training
Bahudhanapati H, Tan J, Jäger B, Li X, Sullivan D, Sembrat J, Rojas M, Valenzi E, Lafyatis R, Jawale C, Biswas P, Tedrow J, Königshoff M, Kaminski N, Wuyts W, Alder J, Zhang Y, Nouraie SM, Prasse A, Kass DJ. Elevated levels of CXCL6 drive matrix expression and correlate with markers of poor outcome in IPF. Eur Respir J. 2021
Valenzi E, Bahudhanapati H, Tan J, Tabib T, Sullivan DI, Sembrat J, Fan L, Chen K, Rojas M, Lafargue A, Felsher DW, Tran PT, Kass DJ, Lafyatis R. Single-Nucleus Chromatin Accessibility Identifies a Critical Role for TWIST1 in IPF Myofibroblast Activity. Eur Respir J. 2023; May 4;2200474
Xie B, Murali A, Vandevender AM, Chen J, Silva AG, Bello FM, Chuan B, Bahudhanapati H, Sipula I, Dedousis N, Shah FA, O'Donnell CP, Alder JK, Jurczak MJ. Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice. ISCIENCE. 2022; 25(12): 105569.
Chandrasekera, P, Perfetto M, Zhuo M, Lu C, Bahudhanapati H, Chen WC, Kulkarni P, Liu J, Yien YY, Li J, Yu C, Wei S. ADAM9 cleaves ephrin-Bs and differentially regulates Wnt and mTOR signaling downstream of Akt in colorectal cancer cells. J. Biol. Chem. 2022; June 30: 102225.
Chen TY, Li X, Goobie GC, Hung CH, Hung TK, Hamilton K, Bahudhanapati H, Tan J, Kass DJ, Zhang Y. Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1. PLoS One. 2021; Dec 31;16(12): e0254466.
Bahudhanapati H, Tan J, Dutta JA, Strock SB, Sembrat J, Àlvarez D, Rojas M, Jäger B, Prasse A, Zhang Y, Kass DJ. MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with Idiopathic Pulmonary Fibrosis. J. Biol. Chem. 2019; 294(13): 5008–5022.
Li J, Perfetto M, Neuner R, Bahudhanapati H, Christian L, Mathavan K, Bridges LC, Alfandari D, Wei S. Xenopus ADAM19 regulates Wnt signaling and neural crest specification through nonproteolytic stabilization of ADAM13. Development. 2018; Apr 4;145(7): pii:dev158154.
Bahudhanapati H, Bhattacharya S, Wei S. Evolution of vertebrate Adam genes; duplication of testicular Adams from ancient Adam9/9-like loci. PLoS One. 2015; Aug 26;10(8): e0136281.
Bahudhanapati H, Zhang Y, Sidhu SS, Brew K. Phage display of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2): Identification of selective inhibitors of Collagenase-1 (MMP-1). J Biol Chem. 2011; 286(36): 31761-70.
Hamze AB, Wei S, Bahudhanapati H, Kota S, Acharya KR, Brew K. Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors. Protein Sci. 2007; 16: 1905-1913.
