The Saloman Lab uses both in vitro and in vivo animal models as well as clinical data to conduct anatomical, behavioral, optogenetic, chemogenetic, Ca2+ Imaging, and cell/molecular studies focused on understanding the role of the nervous system in pancreas homeostasis and disease. Currently, we are investigating several signaling mechanisms that contribute to pancreatitis pain. We are also focused on the role of peripheral nerves and neuro-immune interactions that regulate tumorigenesis and pain.
- BA, Boston University, 2006
- PhD, University of Maryland, 2013
- Post-Doc, University of Pittsburgh, 2017
Education & Training
Saloman JL, Cohen JA, Kaplan DH. Intimate Neuro-immune Interactions: Breaking Barriers Between Systems to Make Meangingful Progress. Curr Opin Neurobiol. 2019; 62: 60-67.
Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM. Ablation of Sensory Neurons in a Genetic Model of Pancreatic Ductal Adenocarcinoma Slows Initiation and Progression of cancer. Proc Natl Acad Sci USA. 2016; 113(11): 3078-83.
Saloman JL, Scheff NN, Snyder LM, Ross SE, Davis BM, Gold MS. Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons. J Neurosci. 2016; 36(42): 10769-81.
Saloman JL, Singhi AD, Hartman DJ, Normolle DP, Albers KM, Davis BM. Systemic Depletion of Nerve Growth Factor Inhibits Disease Progression in a Genetically Engineered Model of Pancreatic Ductal Adenocarcinoma. Pancreas. 2018; 47(7): 856-63.
- Member, International Association for the Study of Pain, 2009-present
- Member, Pittsburgh Center for Pain Research, 2017-present
- Member, American Pancreas Association, 2018-present
- Member, Biobehavioral Oncology Program, Hillman Cancer Center, 2019-present
- Member, American Gastroenterological Association, 2020-present
- Member, US Association for the Study of Pain, 2020-present
- Member, American Association Cancer Research, 2021
R01 CA285585, Peripheral Nerve Regulation of Pancreas Cancer Progression, PI, 2024-2029.
R01 DK136478, Biomarkers to stratify pain severity and type in pancreatic disease, Co-I, 2023-2027.
RF1 NS131165, Validation of Neuropilin-1 receptor signaling in nociceptive processing, Co-I, 2024-2026.
