Dr. Jie Liu’s research interests include the study of mitochondrial function in the context of stem cells, growth, and metabolism; vascular biology; and genetic imprinting of the stimulatory G protein alpha-subunit in human genetic disease psuedohypoparathryroidism type 1B.
- BS, Heilongjiang University, Harbin, China, 1987
- PhD, Academy of Military Medical Sciences, Beijing, China, 1987
- Postdoctoral, Molecular Cardiology, University of Texas Medical Branch, 1997
- Research Fellow, Metabolic Diseases, NIDDK-NIH, 2001
Education & Training
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, XU XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009; 459(7245): 387-392.
Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Reports. 2013; 4(5): 913-920.
Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nature Cell Biology. 2013; 15(12): 1464-1472.
Liu JC, Liu J, Holmström KM, Menazza S, Parks RJ, Fergusson MM, Yu ZX, Springer DA, Halsey C, Liu C, Murphy E, Finkel T. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Reports. 2016; 16(6): 1561-1573.
Liu S, Liu J, Ma Q, Cao L, Fattah RJ, Yu Z, Bugge TH, Finkel T, Leppla SH. Solid tumor therapy by selectively targeting stromal endothelial cells. Proceedings of the National Academy of Science USA. 2016; 113(28): E4079-E4087.
Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013; 501(7465): 63-68.
Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigart R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T. Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nature Medicine. 2013; 19(10): 1281-1287.
Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS. Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. Proceedings of the National Academy of Science USA. 2005; 102(15): 5513-5518.
Liu J, Nealon JG, Weinstein LS. Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB. Human Molecular Genetics. 2005; 14(1): 95-102.
Liu J, Litman D, Rosenberg MJ, Yu S, Biesecker LG, Weinstein LS. A GNAS1 imprinting defect in pseudohypoparathyroidism type IB. Journal of Clinical Investigation. 2000; 106(9): 1167-1174.
- NHLBI Division of Intramural Research Orloff Science Award, 2013
- NHLBI Director's Award for Outstanding Translational Science, 2015
- NHLBI Orloff Innovations Award, 2016
- United States Government Service Award (Brown Medal), 2016
- NHLBI Core Innovation Award, 2017
