CMV infection remains the most common infection in lung transplant recipients (LTRs) and a major cause of morbidity and mortality. Dr McDyer’s research investigates T-bet, the T cell transcriptional factor to determine if it is necessary for protective CMV-specific immunity during acute and chronic CMV infection. To test this he uses both the murine CMV (MCMV) pulmonary infection model and the LTR cohort to study the role of T-bet in pulmonary and systemic CMV host defense and the development of protective T cell memory.
- BS, Chemistry, St. Joseph's University, 1986
- MD, Thomas Jefferson Medical College, 1990
- Residency, Internal Medicine, Barnes Hospital, Washington University, 1993
- Fellowship, Allergy/Immunology, National Institute of Allergy and Infectious Diseases, 1998
- Fellowship, Critical Care/Pulmonary Medicine, NIH Bethesda and Johns Hopkins University, 2002
Education & Training
Popescu, I, Pipeling, MR, Mannem, H, Shah, PD, Orens, JB, Conners, M, Migueles, SA, McDyer, JF. IL-12 Dependent Cytomegalovirus-Specific CD4+ Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control. Journal of Immunology. 2016; Jan 15;196(2): 877-90.
Lendermon, EA, Dodd-o, JM, Coon, TA, Miller, HL, Ganguly, S, Popescu, I, O'Donnell, C, Cardenes, N, Levine, M, Rojas, M, Weathington, NM, Zhao, J, Zhao, Y, McDyer, JF. CD8+IL-17+ T Cells Mediate Neutrophil-predominant Acute Cellular Rejection in T-bet-Deficient Lung Allograft Recipients. American Journal of Respiratory Cell Molecular Biology. 2015; May;52(5): 622-3.
Morrell, MR, Pilewski, JM, Gries, CJ, Pipeling, MR, Crespo, MM, Ensor, CR, Yousem, SA, D'Cunha, J, Shigemura, N, Bermudez, CA, McDyer, JF, Zeevi, A. De novo donor-specific HLA-antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation. Journal of Heart Lung Transplantation. 2014; Dec;33(12): 1288-1294.
Popescu, I, Pipeling, MR, Shah, PD, Orens, JB, McDyer, JF. T-bet: Eomes Balance, Effector Function, and Proliferation of Cytomegalovirus-Specific CD8+ T Cells during Primary Infection Differentiates the Capacity for Durable Immune Control. Journal of Immunology. 2014; Dec 1;193(11): 2709-2722.
Popescu, I, Drummond, MB, Gama, L, Coon, T, Merlo, CA, Wise, RA, Clements, JE, Kirk, GD, McDyer, JF. Activation-induced Cell Death Drives Profound Lung CD4+ T cell Depletion in HIV-associated COPD. American Journal of Respiratory and Critical Care Medicine. 2014; Oct 1;190(7): 744-55.
Akulian, JA, Pipeling, MR, John, ER, Orens, JB, Lechtzin, N, McDyer, JF. High-Quality CMV-specific CD4+ Memory is enriched in the Lung Allograft and is Associated with Mucosal Viral Control. American Journal of Transplantation. 2013; Jan 13(1): 146-56.
Pipeling, MR, John, ER, Orens, JB, Lechtzin, N, McDyer, JF. Primary CMV pp65-specific CD8+ T Cell Responses and T-bet Levels Predict Early Relapsing Viremia in Lung Transplant Recipients. Journal of Infectious Diseases. 2011; 204(11): 1663-71.
Dodd-o, JM, Lendermon, EA, Miller, H, Zhong, Q, John, ER, Jungraithmayer, WM, McDyer, JF. CD154 Blockade Abrogates Allospecific Responses and Enhances CD4+ Regulatory T Cells in Orthotopic Lung Transplant. American Journal of Transplantation. 2011; 11(9): 1815-24.
Pipeling, MR, West, EE, Osborne, CM, Whitlock, AB, Dropulic, LK, Willett, MH, Forman, M, Valsamakis, A, Orens,JB, Moller, DR, Lechtzin, N, Migueles, SA, Conners, M, McDyer, JF. Differential CMV-Specific CD8+ Effector T Cell Responses in the Lung Allograft Predominate Over the Blood during Human Primary Infection. Journal of Immunology. 2008; 181: 546-556.
Gerhardt, SG, McDyer, JF, Girgis, RE, Conte, JV, Yang, SC, Orens, JB. Maintenance Azithromycin for the treatment of Bronchiolitis Obliterans Syndrome. American Journal of Respiratory and Critical Care Medicine. 2003; 168: 121-125.
