Developing therapy to optimize microvascular perfusion. NIH R01 funding to develop technique of sonorepefusion, which is the application of ultrasound to intravascular microbubbles to relieve microvascular obstruction and restore myocardial perfusion in the setting of percutaneous coronary intervention of acute myocardial infarction.
Providing research mentoring for fellows, residents, graduate students and undergraduate students. Providing procedural education to fellows in cardiac catheterization techniques. Community outreach education.
- BS, Carnegie Mellon University, 1990
- MS, Lehigh University, 1992
- MD, University of Pittsburgh, 1998
- Residency, Internal Medicine, University of Pittsburgh, 2000
- Fellowship, Cardiovascular Diseases, University of Pittsburgh, 2004
- Fellowship, Interventional Cardiology, University of Pittsburgh, 2006
Education & Training
Pacella JJ, Kameneva MV, Brands J, Lipowsky HH, VInk H, Lavery LL, Villanueva FS. Modulation of pre-capillary arteriolar pressure with drag reducing polymers: a novel method for enhancing microvascular perfusion. Microcirculation. 2012; 19: 580-585.
Leeman JE, Kim JS, Yu F, Chen X, Kim K, Wang J, Chen X, Villanueva FS, Pacella JJ. Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis. Ultrasound Med Biol. 2012; 38(2): 1589-98.
Kim JS, Leeman JE, Kagemann L, Yu FT, Chen X, Pacella JJ, Schuman JS, Villanueva FS, Kim K. Volumetric quantification of in vitro sonothrombolysis with microbubbles using high resolution optical coherence tomography. J Biomed Opt. 2012; 17(6) Mar-Apr: 070502.
Brands J, Kliner D, Lipowsky HH, Kameneva MV, Villanueva FS, Pacella JJ. New insights into the microvascular mechanisms of drag reducing polymers: effect on the cell-free layer. PLoS One. 2013; 8(10): e77252.
Chen X, Leeman JL, Wang J, Pacella JJ, Villanueva FS. New insights into mechanisms of sonothrombolysis using ultra-high-speed imaging. Ultrasound Med Biol. 2014; 40(1): 258-262.
Webb TN, Ramratnam M, Evans RW, Orchard T, Pacella J, Erkan E. Atherosclerotic renal artery stenosis as a cause for hypertension in an adolescent patient. Pediatr Nephrol. 2014; 29(4): 1457-60.
Pacella JJ, Brands J, Schnatz FG, Chen X, Villanueva FS. Treatment of microvascular micro-embolization using microbubbles and long tone-burst-ultrasound: an in vivo study. Ultrasound Med Biol. 2015; 41(2): 456-564.
Chen X, Wang J, Pacella JJ, Villanueva FS. Dynamic behavior of microbubbles during long ultrasound tone-burst excitation: mechanistic insights into ultrasound-microbubble mediated therapeutics using high-speed imaging and cavitation detection. Ultrasound Med Biol. 2016; 42(2): 528-538.
Helfield B, Black JJ, Qin B, Pacella J, Chen X, Villanueva FS. Fluid viscosity affects the cavitation of lipid encapsulated microbubbles for therapeutic applications. Ultrasound Med Biol. 2016; 42(3): 782-794.
Black JJ, Yu FTH, Schnatz RG, Chen X, Villanueva FS, Pacella JJ. Effect of thrombus composition and viscosity on sonoreperfusion efficacy in a model of microvascular obstruction. Ultrasound Med Biol. 2016; epub in press_May 17, 2016
Title: Ultrasound Targeted Microbubble Cavitation to Treat Coronary Microvascular Obstruction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL157497
Start Year: 2021
End Year: 2026
Title: Hemostasis and Vascular Biology Research Institute - (Pacella)
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Grant Number: RES
Start Year: 2008
End Year: 2028
Title: Hemostasis and Vascular Biology Research Institute - (Pacella)
Role: Co-Investigator
Funding Agency: Vitalant Research Institute
Grant Number: RES
Start Year: 2008
End Year: 2028
