Dr. Shipman studies how the urinary excretion of albumin and other proteins reflects the health of the kidney proximal tubule (PT) and glomerulus. Proteinuria results when the PT cannot fully reclaim proteins that escape the glomerular filtration barrier, and it is strongly associated with the progression of chronic kidney disease (CKD) and with adverse cardiovascular outcomes. Using quantitative imaging in normal and proteinuric mouse models, she aims to builds multiscale mathematical models of PT endocytic capacity that account for sex differences, luminal fluid flow, and protein filtration—both within individual cells and along the length of the tubule. Her long-term goal is to determine how sex, kidney size, and nephron number together shape susceptibility to injury and the trajectory of CKD progression.
- BS, Biology, College of William and Mary, 2015
- PhD, University of Pittsburgh School of Medicine, 2022
Education & Training
Kristensen AM, Bordoni L, Nielsen MB, Kidmose H, Sardella, Shipman KE, Krogstrup NV, Størling J, Birn H, Enger R, and Schiessl IM. In vivo expression of VCAM1 precedes nephron loss following kidney tubular necrosis. Sci. Adv. 11, eadz5358(2025). PMID: 41124249.
Youm E, Shipman KE, Albalawy WN, Vandevender AM, Sipula IJ, Rbaibi Y, Marciszyn AE, Lashway JA, Brown EE, Bondi CB, Boyd-Shiwarski CR, Tan RJ, Jurczak MJ, Weisz OA. Megalin knockout reduces SGLT2 expression and sensitizes to Western diet-induced kidney injury. Function. 2024 Jul 11; 5(4):zqae026. PMID: 38984983.
Lackner EM, Cowan IA, Long KR, Weisz OA, Shipman KE. Fluid Shear Stress-Induced Changes in Megalin Trafficking Enhance Endocytic Capacity in Proximal Tubule Cells. Front Physiol. 2024 Jun 14; 15:140428. PMID: 38948083.
Shipman KE, Baty CJ, Long KR, Rbaibi Y, Cowan IA, Gerges M, Marciszyn AL, Kashlan OB, Tan RJ, Edwards A, Weisz OA. Impaired endosome maturation mediates tubular proteinuria in Dent disease. J Am Soc Nephrol. 2023 Apr; 34(4):619-640. PMID: 36758125.
Shipman KE, Long KR, Cowan IA, Rbaibi Y, Baty CJ, Weisz OA. An adaptable physiological model of endocytic megalin trafficking in OK cells and mouse kidney proximal tubule. Function (Oxf), 2022 Sep 7;3(6):zqac046. PMCID: PMC9614980.
K01 DK140628, Impact of sex, flow, and glomerular permeability on endocytic uptake along the kidney proximal tubule, PI, 2025-2030
