My research aims to identify cellular and molecular mechanisms that provide an advantage to the host by either promoting the pathogen clearance or limiting the pathogen induced tissue damage. My research aims to identify these mechanisms in settings of compromised host such as a host with viral infection or during aging process.
- B.Pharmacy, Gyan Vihar School of Pharmacy, Jaipur, India, 2009
- PhD, St. John’s University, 2015
- Post Doctoral Associate, Yale School of Medicine, 2019
Education & Training
Chang D, Lin M, Wei L, Xie L, Zhu G, Dela Cruz CS, Sharma L. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China. Journal of American Medical Association. 2020; 323 (11): 1092-1093.
Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Yan X, Yang QW, Xu, Zhu HD, Xu YC. Jin Q, Sharma L, Wang L, Wang J. Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clinical Infectious Disease. 2020; 71 (15): 778-785.
De Chang, Mo G, Yuan X, Tao Y, Peng X, Wang FS, Xie L, Sharma L, Dela Cruz CS, Qin E. Time kinetics of viral clearance and resolution of symptoms in novel coronavirus infection. American Journal of Respiratory and Critical Care Medicine. 2020; 201 (9): 1150-1152.
Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis. BMC Infectious Diseases. 2021; 21(1): 1-10.
Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. Coronavirus lung infection impairs host immunity against secondary bacterial infection by promoting lysosomal dysfunction. Journal of Immunology. 2022; 209(7): 1314-1322.
Chang D, Zhao P, Zhang D, Dong JH, Xu z, Yang G, Li by, Liu HX, Li B, Qin CF, Peng X, Wang F, Xie L, Chen Z, Dela Cruz CS, Sharma L, Qin EQ. Persistent viral presence determines the clinical course of the disease in COVID-19. The Journal of Allergy and Clinical Immunology: In Practice. 2020; 8(8): 2585-2591.
Chang D, Lin M, Song N, Zhu Z, Gao J, Li S, Liu H, Liu DZ, Zhang Y, Sun W, Zhou X, Yang B, Li Y, Wang L, Xiao Z, Li K, Xing L, Xie L, Sharma L. The emergence of influenza B as a major respiratory pathogen in the absence of COVID-19 during the 2021–2022 flu season in China. Virology Journal. 2023; 20(1): 1-10.
Najjar-Debbiny R, Barnett-Griness O, Khoury J, Gronich N, Weber G, Adir Y, Shteinberg M, Shneir S, Sharma L, Saliba W. Association between COVID-19 infection and pulmonary fibrosis: a nested case-control study. The American Journal of Medicine. 2023
Sharma L, Peng X, Qing H, Hillard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kang MJ, Ishibe S, Young L H, Kotenko, Compton S, Wilen CB, Wang A, Dela Cruz CS. Distinct roles of type I and type III interferons during a native murine ß coronavirus lung infection. Journal of Virology. 2022; 96(2): e01241-21.
Xie C, Li Q, Li L, Peng X, Ling Z, Xiao B, Feng J, Chen Z, Chang D, Xie L, Dela Cruz CS, Sharma L. Association of early inflammation with age and asymptomatic disease in COVID-19. Journal of Inflammation Research. 2021; 1207-1216.
- American Lung Association Study Section, 2018-2022
- Parker B Francis Fellowship, 2020
- Rising Star, Pulmonary Infections and Tuberculosis Assembly, American Thoracic Society, 2020
