My research focuses on identifying steroid resistant pathways of inflammation in severe asthma. We have previously identified Type 1 inflammation, manifested by Interferon-gamma elevation in the lung, as a phenotype of severe asthma. My current work seeks to better understand the immune mechanisms leading to persistence of Type 1 inflammation in severe asthma and how this impacts disease severity and response to currently available asthma therapies.
My clinical interest is in the diagnosis and management of patients with severe asthma. This includes management of common asthma comorbidities and newly developed biologic therapies for severe asthma.
My educational interests focus on teaching medical students about asthma physiology, diagnosis and management. I also have an educational focus on critical care training for residents through the teaching services in the ICU setting.
- BA, Vanderbilt University, 2005
- MD, Vanderbilt University, 2009
- Residency, Internal Medicine, University of Pittsburgh, 2012
- Fellowship, Pulmonary, Allergy & Critical Care Medicine, University of Pittsburgh, 2016
Education & Training
Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A. Severe Asthma in Humans and Mouse Model Suggests a CXCL10 Signature Underlies Corticosteroid-resistant Th1 Bias. JCI Insight. 2017; Jul 6; 2(13): e94580.
Gauthier M, Ray A, Wenzel SE. Evolving Concepts of Asthma. Am J Respir Crit Care Med. 2015; 192(6): 660-8.
- History of Medicine Lecture Prize, Vanderbilt University School of Medicine, 2008
- 12th Annual Respiratory Disease Young Investigators’ Forum, 2016
- 14th Annual Respiratory Disease Young Investigators’ Forum, 2018
- American Thoracic Society, Abstract Award, 2018
- Parker B. Francis Award, 2018
