The focus of Dr. Snyder's research is on the role of the adaptive immune system in the development of chronic rejection after lung transplantation. Chronic rejection is a progressive airway disease which remains a major limiting factor to long term survival following lung transplantation. Imbalances in the suppression of the adaptive immune system, leading to acute rejection or infection, have been implicated in the pathogenesis of chronic rejection.
Recently, Dr. Snyder identified that lung donor memory T cells, the predominant cell in the adaptive immune system, survive following transplantation and persist for weeks to months in the recipient. Furthermore, this survival of donor T cells is associated with improved short-term outcomes. Additionally, his group showed that lung allograft-infiltrating, recipient-derived T cells which migrate to the lungs following transplantation take up residency within the lung. His lab is focusing on determining the function and specificity of these tissue-resident memory T cells and if they are contributing to chronic rejection.
In addition to lung transplantation, the Snyder lab is actively investigating the role of tissue resident memory T cells on pulmonary fibrosis and chronic airway inflammation.
Dr. Snyder's main clinical interests focus on the management of patients with end stage lung disease and the care of lung transplant recipients. He manages the outpatient care of lung transplant recipients at the Falk Comprehensive Lung Center as well as providing inpatient care with the advanced lung disease service at Presbyterian Hospital.
Dr. Snyder provides educational instruction on the inpatient advanced lung disease and postoperative lung transplantation services. Additionally, Dr. Snyder provides mentorship in translational investigation through his laboratory.
- BA, Economics, Cornell University, 2001
- MD, SUNY Stony Brook University School of Medicine, 2010
- Residency, Internal Medicine, Columbia-New York Presbyterian Hospital, 2013
- Chief Resident, Internal Medicine, Columbia-New York Presbyterian Hospital, 2014
- Clinical Fellowship, Pulmonary, Columbia-New York Presbyterian Hospital, 2017
- Research Fellowship, Pulmonary, Columbia-New York Presbyterian Hospital, 2018
Education & Training
Snyder ME, Moghbeli K, Bondonese A, Craig A, Popescu I, Fan L, Tabib T, Lafyatis R, Chen K, Trejo Bittar HE, Lendermon E, Pilewski J, Johnson B, Kilaru S, Zhang Y, Sanchez PG, Alder JK, Sims PA, McDyer JF. Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation. J Exp Med. 2022; Apr 4;219(4): e20212059.
Szabdo PA, Levitin HM, Miron M, Snyder ME, Senda T, Yuan J, Cheng YL, Bush EC, Dogra P, Thapa P, Farber DL, Sims PA. Single cell transcriptome profiling defines activation states and interrelatedness between human blood and tissue T cells. Nature Communications. 2019; 10:4076
Weisberg SP, Carpenter DJ, Chait M, Dogra P, Gartrell-Corrado RD, Chen AX, Campbell S, Liu W, Saraf P, Snyder ME, Kubota M, Danzi NM, Schrope BA, Rabadan R, Saenger Y, Chen X, Farber DL. Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway. Cell Rep. 2019; Dec 17;29(12): 3916-3932.e5.
Snyder ME, Finlayson MO, Connors TJ, Senda T, Bush E, Carpenter D, Marboe C, Benvenuto L, Shah L, Robbins H, Hook JL, Sykes M, D'Ovidio F, Bacchaetta M, Sonett JR, Lederer DJ, Arcasoy S, Sims PA, Farber DL. Generation and persistence of human tissue-resident memory T cells in lung transplantation. Science Immunology. 2019; Mar 8; 4(33): eaav5581
Senda T, Dogra P, Granot T, Furuhaushi K, Snyder ME, Carpenter DJ, Szabo PA, Thapa P, Miron M, Farber DL. Macroanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunology. 2018; In Press
Snyder MD, Farber DL. Thymic-Peripheral Crosstalk in Lymphodepletion Therapy. Am J Transplant. 2017; 17(8): 1970-71.
Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med. 2014; 190(9): 1012-1021.
- Transplantation and Immunology Research Network: Fellowship Grant, 2017
- Parker B. Francis Fellowship, 2018
