Idiopathic Pulmonary Fibrosis (IPF) is a fatal and progressive lung disease, characterized by progressive scarring of the lung. IPF prevalence dramatically increases with age, and aging is a known risk factor for IPF. However, there is limited understanding in the mechanisms involved in the increased vulnerability of the aging lung to develop lung fibrosis. Our published findings were pioneered to identify alterations in mitochondrial homeostasis in the aging type alveolar epithelial cell (AECII) as a critical component of the pathogenesis of IPF. Currently, our studies are extending to other diseases characterized by abnormal tissue repair and exaggerated remodeling, including pulmonary hypertension (PH) and scleroderma.
- BSc, Biochemistry, University of Zaragoza, Spain, 2000
- Master in Biochemistry, University of Zaragoza, Spain, 2006
- PhD, Biochemistry (Protein Folding and Molecular Design), University of Zaragoza, Spain, 2006
- Erasmus Fellowship, University of Geneva, Switzerland, 2000
- Thomas E. Starzl Transplantation Fellowship, University of Pittsburgh School of Medicine, 2007
Education & Training
Bueno, M., Lai, Y. C., Romero, Y., Brands, J., St Croix, C. M., Kamga, C., Corey, C., Herazo-Maya, J. D., Sembrat, J., Lee, J. S., Duncan, S. R., Rojas, M., Shiva, S., Chu, C. T., Mora, A. L. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. Journal of Clinical Investigation. 2015; 125(2): 521-38.
Torres-González, E., Bueno, M., Tanaka, A., Krug, L. T., Cheng, D. S., Polosukhin, V. V., Sorescu, D., Lawson, W. E., Blackwell, T. S., Rojas, M., Mora, A. L. Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2012; 46(6): 748-56.
Bueno, M., Wang, J., Mora, A. L., Gladwin, M. T. Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics. Antioxidants & Redox Signaling. 2013; 18(14): 1797-809.
Acín-Pérez, R., Bayona-Bafaluy, M.P., Bueno, M., Machicado, C., Fernández-Silva, P., Pérez-Martos, A., Montoya, J, Lopez-Perez, M. J., Sancho, J., Antonio Enríquez, J. An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA. Human Molecular Genetics. 2003; 12(3): 329-339.
Chunqing, L, Bueno, M., Kant, J, Martinson, J, Randhawa, P. Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysis. Journal of virology. 2009; 83(9): 2285-2297.
Bueno, M., Fillat, M. F., Strasser, R. J., Maldonado-Rodriguez, R., Marina, N, Smienk, H, Gómez-Moreno, C, Barja, F. Effects of lindane on the photosynthetic apparatus of the cyanobacteriumanabaena. Environmental Science and Pollution Research. 2004; 11(2): 98-106.
