Dr. Nguyen's multiple research interests are medical mycology research, including projects on the mechanisms and clinical impact of antifungal drug resistance, and molecular pathogenesis of invasive Candida infections. Since 2016, she extended her interest in Zygomycetes genetics and epidemiology. In addition, her research focuses on XDR bacterial and antimicrobial stewardship research, including projects on evolution and tolerance/resistance and pathogenic mechanisms of carbapenem-resistant Enterobacteriaceae (CRE) and other Gram negative bacteria; the development of novel antibiotic treatment strategies based upon bacterial genetics and pharmacokinetic-pharmacodynamic (PK-PD) principles; the clinical and economic impact of XDR infections and antimicrobial stewardship interventions; and clinical trials of new antimicrobials and diagnostic tests. Dr. Nguyen's Transplant Infectious Diseases (TID) research includes projects on the role of the microbiome in infections and outcomes among transplant recipients, the impact of rectal CRE carriage on transplant patients' outcome, and clinical studies and trials on a wide range of opportunistic fungal, bacterial, and viral infections.
- BS, Chemistry and Physics, Elizabeth College, 1984
- MD, Temple University School of Medicine, 1988
- Residency, Internal Medicine, University of Pittsburgh School of Medicine, 1991
- Fellowship, Infectious Diseases, University of Pittsburgh Health Center, 1995
Education & Training
Cheng, S, Clancy, CJ, Xu, W, Schneider, F, Hao, B, Mitchell, AP, Nguyen, MH. Profiling of Candida albicans gene expression during intra-abdominal candidiasis identifies biologic processes involved in pathogenesis. Journal of Infectious Diseases. 2013; 208(9): 1529-37.
Cheng, S, Clancy, CJ, Hartman, DJ, Hao, B, Nguyen, MH. Candida glabrata intra-abdominal candidiasis is characterized by persistence within the peritoneal cavity and abscesses. Infection and Immunity. 2014; 82(7): 3015-22.
Vergidis, P, Clancy, CJ, Shields, RK, Park, SY, Wildfeuer, BN, Simmons, RL, Nguyen, MH. Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment. PLoS One. 2016; 11(4): e0153247.
Eschenauer, GA, Kwak, EJ, Humar, A, Potoski, BA, Clarke, LG, Shields, RK, Abdel-Massih, R, Silveira, FP, Vergidis, P, Clancy, CJ, Nguyen, MH. Targeted versus universal antifungal prophylaxis among liver transplant recipients. American Journal of Transplantation. 2015; 15(1): 180-9.
Haidar, G, Alkroud, A, Cheng, S, Churilla, TM, Churilla, BM, Shields, RK, Doi, Y, Clancy, CJ, Nguyen, MH. Association between presence of aminoglycoside modifying enzymes and in vitro activity of gentamicin, tobramycin, amikacin and plazomicin against KPC and ESBL-producing Enterobacter spp. Antimicrobial Agents and Chemotherapy. 2015; AAC.00869-16.
