The Al-bataineh Lab is interested in understanding the role of transmembrane glycoprotein Mucin 1 (MUC1) in urinary tract system in health and diseases states. In a new direction for his lab, Dr. Al-bataineh now evaluates the role of MUC1 in urinary tract host defense and cellular signaling during urinary tract infections. This project is the focus of his R01 grant.
Dr. Al-bataineh received his DVM and Master’s degree in Physiology and Pharmacology from Jordan University of Science and Technology. He completed his PhD in Clinical Pharmacology from Kansas State University, KS where he studied the carrier-mediated transport processes of xenobiotic molecules across mammary epithelial cells. His postdoctoral studies at the University of Pittsburgh (Pitt) focused on studying the regulation of the V-ATPase and AQP2 by kinases in the kidney. This work was supported by a Fellowship from SANOFI (Genzyme) and an NIH fellowship (F32), respectively. Subsequently, he received an NIH K01 award to test the hypothesis that MUC1 is protective during ischemia-reperfusion injury (IRI) through transactivation of the b-catenin protective pathway. He also has expanded his research focus to further investigate the role of MUC1/HIF-1a complex in kidney protection during IRI, a project supported by his NIH R03 grant.
Dr. Al-bataineh also teaches Keystone Fundamentals and Organ systems for the first- and second-year Medical students. This role is part of Pitt Med new Three Rivers Curriculum (3RC), which focuses on helping our medical students learn the core knowledge needed to pass Step 1 and start their clinical rotations.
- DVM, Jordan University of Science and Technology, 2000
- MS, Physiology & Pharmacology, Jordan University of Science and Technology, 2002
- PhD, Clinical Pharmacology, Kansas State University, 2010
- Post-doctoral Associate, University of Pittsburgh, 2012
- Post-doctoral Scholar, University of Pittsburgh, 2016
Education & Training
Manrique-Caballero CL, Barasch J, Zaidi SK, Bates CM, Ray EC, Kleyman TR, Al-Bataineh MM. Expression and distribution of MUC1 in the developing and adult kidney. Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F107-F120. PMID: 39588770.
Al-Bataineh MM, Kinlough CL, Marciszyn A, Lam T, Ye L, Kidd K, Maggiore JC, Poland PA, Kmoch S, Bleyer A, Bain DJ, Montalbetti N, Kleyman TR, Hughey RP, Ray EC. Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis. J Biol Chem. 2023 Mar;299(3):102925. PMID: 36682497.
Al-Bataineh MM, Kinlough CL, Mi Z, Jackson EK, Mutchler SM, Emlet DR, Kellum JA, Hughey RP. KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2021 Aug 1;321(2):F135-F148. PMID: 34151589.
Al-Bataineh MM, Sutton TA, Hughey RP. Novel roles for mucin 1 in the kidney. Curr Opin Nephrol Hypertens. 2017 Sep;26(5):384-391. PMID: 28622163.
Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F890-F900. PMID: 27534994.
Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1216-28. PMID: 26911844.
Al-Bataineh MM, Kinlough CL, Poland PA, Pastor-Soler NM, Sutton TA, Mang HE, Bastacky SI, Gendler SJ, Madsen CS, Singh S, Monga SP, Hughey RP. Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F569-79. PMID: 26739894.
Roy A, Al-bataineh MM, Pastor-Soler NM. Collecting duct intercalated cell function and regulation. Clin J Am Soc Nephrol. 2015 Feb 6;10(2):305-24. PMID: 25632105.
Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014 Sep;10(9):707-9. PMID: 25064832.
Al-bataineh MM, Gong F, Marciszyn AL, Myerburg MM, Pastor-Soler NM. Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2014 May 1;306(9):F981-95. PMID: 24553431.
R01 DK135862, Role of MUC1 in the host defense against urinary tract infection, PI, 2024-2029
R01 DK139177, Regulation of Renal Tubular Mg2+ Handling by MUC1 and Lactation, Co-Investigator, 2025-2029
