Dr. Al-bataineh Lab is interested in understanding the role of transmembrane glycoprotein Mucin 1 (MUC1) in urinary tract system in health and diseases states. In a new direction for his Lab, Dr. Al-bataineh now evaluates the role of MUC1 in urinary tract host defense and cellular signaling during urinary tract infections. This project is the focus of his R01 grant.
Dr. Al-bataineh received his DVM and Master’s degree in Physiology and Pharmacology from Jordan University of Science and Technology. He completed his PhD in Clinical Pharmacology from Kansas State University, KS where he studied the carrier-mediated transport processes of xenobiotic molecules across mammary epithelial cells. His postdoctoral studies at the University of Pittsburgh (Pitt) focused on studying the regulation of the V-ATPase and AQP2 by kinases in the kidney. This work was supported by a Fellowship from SANOFI (Genzyme) and an NIH fellowship (F32), respectively. Subsequently, he received an NIH K01 award to test the hypothesis that MUC1 is protective during ischemia-reperfusion injury (IRI) through transactivation of the b-catenin protective pathway. He also has expanded his research focus to further investigate the role of MUC1/HIF-1a complex in kidney protection during IRI, a project supported by his NIH R03 grant.
Dr. Al-bataineh also teaches Keystone Fundamentals and Organ systems for the first- and second-year Medical students. This role is part of Pitt Med new Three Rivers Curriculum (3RC), which focuses on helping our medical students learn the core knowledge needed to pass Step 1 and start their clinical rotations.
- DVM, Jordan University of Science and Technology, 2000
- MS, Physiology & Pharmacology, Jordan University of Science and Technology, 2002
- PhD, Clinical Pharmacology, Kansas State University, 2010
- Post-doctoral Associate, University of Pittsburgh, 2012
- Post-doctoral Scholar, University of Pittsburgh, 2016
Education & Training
Al-Bataineh MM, Sutton TA, Hughey RP. Novel roles for mucin 1 in the kidney. Current Opinion in Nephrology and Hypertension. 2017; 26(5): SEP 2017: 384–391.
Al-Bataineh, MM, Kinlough, CL, Poland, PA, Pastor-Soler, NM, Sutton, TA, Mang, HE, Bastacky, SI, Gendler, SJ, Madsen, CS, Singh, S, Monga, SP, Hughey, RP. Muc1 enhances the beta-catenin protective pathway during ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2016
Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. American journal of physiology. Renal physiology. 2016; Nov 1; 311(5): F890–F900.
Al-Bataineh, MM, Gong, F, Marciszyn, A, Myerburg, MM, Pastor-Soler, NM. Regulation of Proximal Tubule Vacuolar H+-ATPase by PKA and AMP-Activated Protein Kinase. American journal of physiology. Renal physiology. 2014; 306(9): F981-995.
Al-Bataineh, MM, Alzamora, R, Ohmi, K, Ho, PY, Marciszyn, A, Gong, F, Li, H, Hallows, KR, Pastor-Soler, NM. Aurora Kinase A Activates the Vacuolar H+-ATPase (V-ATPase) in Kidney Carcinoma Cells. American journal of physiology. Renal physiology. 2016
Roy, A & Al-bataineh, MM, Pastor-Soler, NM. Collecting Duct Intercalated Cell Function and Regulation. Clinical journal of the American Society of Nephrology. 2015; 10(2): 305-324.
Gidon, A, Al-Bataineh, MM, Jean-Alphonse, FG, Stevenson, HP, Watanabe, T, Louet, C, Khatri, A, Calero, G, Pastor-Sole, NM, Gardella, TJ, Vilardaga, JP. Endosomal G protein-coupled receptor signaling turned off by negative feedback actions of PKA and v-ATPase. Nature chemical biology. 2014; 10(9): 707-709.
Alzamora, R, Al-Bataineh, MM, Liu, W, Gong, F, Li, H, Thali, RF, Joho-Auchli, Y, Brunisholz, RA, Satlin, LM, Neumann, D, Hallows, KR, Pastor-Soler, NM. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. American journal of physiology. Renal physiology. 2013; 305(7): F943-956.
Pastor-Soler, NM, Sutton, TA, Mang, HE, Kinlough, CL, Gendler, SJ, Madsen, CS, Bastacky, SI, Ho, J, Al-Bataineh, MM, Hallows, KR, Singh, S, Monga, SP, Al-BKobayashi, H, Haase, VH, Hughey, RP. Muc1 is Protective in a Mouse Model of Kidney Ischemia-Reperfusion Injury. American journal of physiology. Renal physiology. 2015; 308(12): F1452-1462.
Rondanino, C, Poland, PA, Kinlough, CL, Li, H, Rbaibi, Y, Myerburg, MM, Al-bataineh, MM, Kashlan, OB, Pastor-Soler, NM, Hallows, KR, Weisz, OA, Apodaca, G, Hughey, RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. American journal of physiology. Renal physiology. 2011; 301(3): F622-633.
Title: Role of MUC1 in the host defense against urinary tract infection.
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK135862
Start Year: 2024
End Year: 2029
Title: MUC1 in distal nephron adaptation to demineralizing stressors.
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & kidney disease
Grant Number: R01
Start Year: 2024
End Year: 2029
