Research in the Weisz lab focuses broadly on understanding how membrane traffic in proximal tubule cells responds to physiologic cues to maintain kidney function. Her team is unraveling the mechanisms by which newly synthesized proteins are sorted and delivered to the appropriate plasma membrane domains of differentiated kidney cells. Additionally, she has been generating new in vitro and ex vivo systems, including disease models, with which to unravel how proximal tubule cells in the kidney alter their endocytic and ion transport capacity in response to changes in tubular flow and the accompanying fluid shear stress. Her studies have direct implications for the understanding and treatment of genetic and other disorders that result in tubular proteinuria and eventually lead to kidney failure, including Lowe syndrome and sickle cell disease.
- BS, Yale University, 1984
- PhD, Johns Hopkins Medical School, 1990
- Postdoctoral Fellow, Johns Hopkins Medical School, 1995
Education & Training
Raghavan V, Rbaibi R, Pastor-Soler N, Carattino MD, Weisz OA. Shear stress dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci USA. 2014; 111: 8506-8511.
Ren Q, Weyer K, Rbaibi Y, Long KR, Tan RJ, Nielsen R, Christensen EI, Baty CJ, Kashlan OB, Weisz OA. Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin. Am J Physiol Renal Physiol. 2020
Long KR, Rbaibi Y, Gliozzi ML, Weisz OA. Differential kidney proximal tubule cell responses to protein overload by albumin and its ligands. Am J Physiol Renal Physiol. 2020; 318: F851-F859.
Gliozzi ML, Espiritu E, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA. Effects of proximal tubule shortening on protein excretion in a Lowe Syndrome model. J Am Soc Nephrol. 2020; 31: 67-83.
Gliozzi ML, Rbaibi Y, Long KR, Vitturi DA, Weisz OA. Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease. Am J Physiol Cell Physiol. 2019; 317: C993-C1000.
Ren Q, Gliozzi ML, Rittenhouse NL, Edmunds LR, Rbaibi Y, Locker JD, Poholek AC, Jurczak MJ, Baty CJ, Weisz OA. Shear stress and oxygen availability drive differential changes in OK proximal tubule cell metabolism and endocytosis. Traffic. 2019; 20: 448-459.
Long KR, Shipman KE, Rbaibi Y, Menshhikova E, Ritov VB, Eshbach Ml, Jiang Y, Jackson EK, Baty CJ, Weisz OA. Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell. 2017; 28: 2508-2517.
Eshbach ML, Kaur A, Rbaibi Y, Tejero J, Weisz OA. Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. Am J Physiol Cell Physiol. 2017; 312: C733-C740.
- President, The Johns Hopkins Postdoctoral Associatoion, 1994-1995
- Member at large, School of Medicine Executive Committee, 2008-2011
- Editorial Board, Physiological Reviews, 2009-
- Academy of Master Educators, 2009-
- Fellow, Executive Leadership in Academic Medicine, 2010-2011
- Johns Hopkins Society of Scholars, 2014
- Distinguished Mentor Award, School of Medicine, 2014
- Board of Scientific Counselors, NIH NHLBI, 2014-
- University of Pittsburgh Postdoctoral Association Advocate Award, 2015
- Council, American Society of Cell Biology, 2016-
