Cardiovascular disease is the leading cause of death in developed countries. Inflammation aggravates outcome of cardiovascular disease including atherosclerosis and infarct healing after myocardial infarction (MI). During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons.
Another area of my research interest is fate and differentiation of hematopoietic stem and progenitor cells in cardiovascular disease. Hematopoietic stem cells get activated after acute or chronic inflammation and give rise to exaggerated myelopoiesis. However, most hematopoietic stem cells (HSC) are quiescent, and it is currently unknown whether they respond to ischemic organ injury. We identified a CCR2+ HSC subset, which has fourfold higher proliferative rate than CCR2- HSC, as the most upstream contributor to myelopoiesis after myocardial infarction. CCR2+ HSC display bias towards the myeloid lineage and dominate the migratory HSC population after myocardial infarction and in steady-state. These data shed new light on the regulation of emergency hematopoiesis after ischemic injury and identify novel therapeutic targets to modulate leukocyte output after myocardial infarction.
- DVM, West Bengal University of Animal and Fishery Sciences, India, 2003
- MS, Wichita State University, 2006
- PhD, University of Wisconsin-Madison, 2010
- Postdoctoral Training, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 2013
Education & Training
Dutta P, Sager H, Stengel K, Naxerova K, ..., Libby P, Hiebert S, Scadden D, Swirski FK, Weissleder R, Nahrendorf M. Myocardial infarction activates CCR2+ hematopoietic stem cells. Cell Stem Cell. 2015; 16: 477-487.
Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, DaSilva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 in atherosclerosis. Journal of Experimental Medicine. 2015; 212: 497-512.
Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Targeting interleukin-1beta reduces leukocyte production after acute myocardial infarction. Circulation. 2015; 132(20): 1880-1890.
Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, THompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, ..., Nahrendorf M. Myocardial infarction accelerates atherosclerosis. Nature. 2012; 487: 325-329.
Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Chronic variable stress activates hematopoietic stem cells. Nature Medicine. 2014; 20: 754-758.
Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, ..., Nahrendorf M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nature Biotechnology. 2011; 29: 1005-1010.
Dutta P, Dart M, Roenneburg DA, Torrealba JR, Burlingham WJ. Pretransplant immune-regulation predicts allograft tolerance. American Journal of Transplantation. 2011; 11: 1296-1301.
Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, Torrealba JR, Burlingham WJ. Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood. 2009; 114: 3578-3587.
- National Merit Scholarship, 1996
- Ray Owen Registration Award at Midwinter Conference of Immunologists, 2008
- University of Wisconsin-Madison Vilas Travel Grant, 2009
- American Society of Transplantation Basic Science Fellowship, 2012
- MGH Scientific Advisory Committee 2012 Poster Distinction Award, 2012
- American Heart Association Fellowship, 2012
- Keystone Symposia Future of Science Fund Scholarship, 2014
- Featured Scientist in Fall 2014 TPEN Newsletter, 2014
