Dr. Duerr holds the Inflammatory Bowel Disease Genetic Research Chair and is a Professor of Medicine, Human Genetics, and Clinical and Translational Science at the University of Pittsburgh. He is Co-Director and Scientific Director of the University of Pittsburgh Medical Center Inflammatory Bowel Disease Center and has been involved in research related to inflammatory bowel disease throughout his career.
He serves on the Management Committee of the International IBD Genetics Consortium, participates in the Gut Cell Atlas initiative funded by the The Leona M. and Harry B. Helmsley Charitable Trust, and previously served as the Associate Chief Scientist for Translational Research on the Leadership Team for the Crohn's & Colitis Foundation's IBD Plexus research and information exchange platform. His research program has had uninterrupted funding from the NIH, the Crohn's & Colitis Foundation, and other foundations since 1995.
Dr. Duerr is a member of the American Gastroenterological Association, American Society of Human Genetics, and Crohn's & Colitis Foundation. He has been an invited lecturer in local, national and international venues, and he has published original inflammatory bowel disease genetics research articles in journals such as Nature, Science, Nature Genetics, American Journal of Human Genetics, and Human Molecular Genetics. He has served on grants review committees for the NIH and Crohn's & Colitis Foundation.
- BS, University of Minnesota - Duluth, 1979
- MD, University of Minnesota, 1983
- Training Program, Internal Medicine, University of California San Francisco, 1986
- Integrated Training Program, Digestive Diseases, University of California Los Angeles, 1990
Education & Training
Huang, H., Fang, M., Jostins, L., Umicevic Mirkov, M., Boucher, G., Anderson, C.A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., ..., Duerr, R.H., Mathew, C.G., Rioux, J.D., McGovern, D.P.B., Cho, J.H., Georges, M., Daly, M.J., Barrett, J.C. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature. 2017; 547(7662): 173-178.
Li, D., Achkar, J.P., Haritunians, T., Jacobs, J.P., Hui, K.Y., D'Amato, M., Brand, S., Radford-Smith, G., Halfvarson, J., Niess, J.H., Kugathasan, S., Buning, C., Schumm, L.P., Klei, L., Ananthakrishnan, A., Aumais, G., ..., Braun, J., McGovern, D.P., Duerr, R.H. A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition. Gastroenterology. 2016; 151(4): 724-32.
Chuang, L.S., Villaverde, N., Hui, K.Y., Mortha, A., Rahman, A., Levine, A.P., Haritunians, T., Ng, S.M., Zhang, W., Hsu, N.Y., Facey, J.A., Luong, T., Fernandez-Hernandez, H., Li, D., ..., Duerr, R.H., Merad, M., McGovern, D.P., Peter, I., Cho, J.H. A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF. Gastroenterology. 2016; 151(4): 710-723.
Cleynen, I., Boucher, G., Jostins, L., Schumm, L.P., Zeissig, S., Ahmad, T., Andersen, V., Andrews, J.M., Annese, V., Brand, S., Brant, S.R., Cho, J.H., Daly, M.J., Dubinsky, M., Duerr, R.H., ..., Radford-Smith, G., McGovern, D.P., Barrett, J.C., Lees, C.W. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet. 2016; 387(10014): 156-67.
Adamik, J., Henkel, M., Ray, A., Auron, P.E., Duerr, R., Barrie, A. The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells. Cytokine. 2013; 64(1): 404-12.
Jostins, L., Ripke, S., Weersma, R.K., Duerr, R.H., McGovern, D.P., Hui, K.Y., Lee, J.C., Schumm, L.P., Sharma, Y., Anderson, C.A., Essers, J., Mitrovic, M., Ning, K., Cleynen, I., Theatre, E., Spain, S.L., Raychaudhuri, S., ..., Barrett, J.C., Cho, J.H. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012; 491(7422): 119-24.
Achkar, J.P., Klei, L., de Bakker, P.I., Bellone, G., Rebert, N., Scott, R., Lu, Y., Reguiero, M., Brzezinski, A., Kamboh, M.I., Fiocchi, C., Devlin, B., Trucco, M., Ringquist, S., Roeder, K., Duerr, R.H. Amino acid position 11 of HLA-DRB1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes and Immunity. 2012; 13(3): 245-52.
Silverberg, M.S., Cho, J.H., Rioux, J.D., McGovern, D.P., Wu, J., Annese, V., Achkar, J.P., Goyette, P., Scott, R., Xu, W., Barmada, M.M., Klei, L., Daly, M.J., Abraham, C., Bayless, T.M., Bossa, F., Griffiths, A.M., ..., Roeder, K., Duerr, R.H. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nature Genetics. 2009; 41(6): 216-20.
Silverberg, M.S., Duerr, R.H., Brant, S.R., Bromfield, G., Datta, L.W., Jani, N., Kane, S.V., Rotter, J.I., Schumm, P.L., Steinhart, H.A., Taylor, K.D., Yang, H., Cho, J.H., Rioux, J.D., Daly, M.J., NIDDK IBD Genetics Consortium. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. European Journal of Human Genetics. 2007; 15(3): 328-35.
Duerr, R.H., Taylor, K.D., Brant, S.R., Rioux, J.D., Silverberg, M.S., Daly, M.J., Steinhart, A.H., Abraham, C., Regueiro, M., Griffiths, A., Dassopoulos, T., Bitton, A., Yang, H., Targan, S., Datta, L.W., Kistner, E.O., Schumm, L.P., ..., Nicolae, D.L., Cho, JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006; 314(5804): 1461-3.
- Member, American Gastroenterological Association, 1992 - Present
- Crohn’s & Colitis Foundation Grants Review Committee, 1996 -1999, 2009 - 2011
- Physician of the Year, Crohn’s & Colitis Foundation, Western Pennsylvania/West Virginia Chapter, 2000
- Editor, Genetics Section, Inflammatory Bowel Diseases, 2002-2006, 2008 – 2011
- Principal Investigator of NIDDK IBD Genetic Consortium Genetic Research Center, 2002 - Present
- Member, American Society of Human Genetics, 2003 - Present
- Ad Hoc member of Genetics of Health and Disease NIH Study Section and NIH Special Emphasis Panels, 2008, 2009, 2012, 2016
- Inflammatory Bowel Disease Genetic Research Chair, 2011 - Present
- Crohn's & Colitis Foundation IBD Plexus Integration and Transition Team Member, 2014 - 2015
- Crohn's & Colitis Foundation IBD Plexus Associate Chief Scientist, Translational Research, 2015 - Present
