My research interest has been the molecular biology of leukemic transformation and myeloid differentiation. A major focus of my laboratory has been the mechanism underlying differentiation arrest in myeloid leukemia, investigating acute promyelocytic leukemia (APL) as a model system. My group first cloned the NPM-RAR translocation that characterizes the t(5;17) variant of APL, and we have had an active program studying the mechanism by which NPM-RAR generates the leukemic phenotype. I am a physician/scientist in the Division of Hematology/Oncology in the Department of Medicine, and a member of the Cancer Therapeutics Program of the University of Pittsburgh Cancer Institute.
- BS, Yale College, 1976
- MD, Harvard Medical School, 1980
- Residency, Osler Medical Service, The Johns Hopkins Hospital, 1983
- Fellowship, UCLA, 1984
- Medical Staff Fellow, Clinical Hematolgy Branch, NHLBI, NIH, 1991
Education & Training
Chattopadhyay A, Abecassis I, Redner RL. NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NF?B and JNK. Leukemia and Lymphoma. Leukemia and Lymphoma. 2015; 56(12): 3401-6.
Johnson DE, Redner RL. An ATRActive future for differentiation therapy in AML. Blood Reviews. 2015; 29(4): 215-280.
Chattopadhyay A, Hood BL, Conrads TP, Redner RL. Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD. Molecular Cancer Research. 2014; 12: 1283-1291.
Kropf P, Wang L, Zhang Y, Redner R, Johnson D. Dasatinib promotes ATRA-induced differentiation of AML cells. Leukemia. 2010; 24(3): 663-5.
Miranda M, Duan R, Thomas SM, Grandis JR, Redner RL. Gefitinib potentiates myeloid cell differentiation by ATRA. Leukemia. 2008; 22: 1624-7.
Miranda MB, Redner RL, Johnson DE. Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation. Molecular Cancer Therapeutics. 2007; 6: 3081-90.
Rego EM, Ruggero D, Tribioli C, Cattoretta G, Kogan S, Render RL. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. 2006; 25(13): 1974-9.
Redner RL, Chen JD, Rush EA, Li H, Pollock SL. Acute Promyelocytic Leukemia Fusion Protein NPM-RAR Interacts with Co-repressor and Co-activator Proteins and Exhibits both Positive and Negative Transcriptional Properties. Blood. 2000; 95: 2683-2690.
Redner RL, Corey SJ, Rush EA. Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid. Leukemia. 1997; 11: 1014-1016.
Redner RI, Rush EA, Faas S, Rudert WA, Corey SJ. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood. 1996; 87(3): 882-886.
- Visiting Professor, Nippon Medical School, Tokyo, Japan, 1996
- Visiting Professor, Jinchi Medical School, Tochigi, Japan, 1996
- The Dr. Samuel Dorantes Meza Talk, Mexican Society of Hematology, 2002
- Visiting Professor, Asahi General Hospital, Chiba Japan, 2004
- Plenary Speaker, Pan-Asia Hematology/Oncology Summit, 2008
- Visiting Professor, University of Vermont, 2010
- Visiting Professor, West Virginia Medical Centre, 2013
- Adrianna M. Salvaggio, MD Dedication to Commitment and Quality Award, Shadyside Hospital, 2013
