Dr. O'Doherty's overarching research interests are in questions related to the association between states of over nutrition and resulting metabolic disturbances, most notably obesity, NAFLD, and Type 2 Diabetes. Dr. O'Doherty has accumulated nearly twenty five years experience in this arena, utilizing a range of metabolic, physiological, biochemical, molecular and immunological approaches in a range of models, notably the mouse and rat, primary tissue culture, and immortal cell lines. The major foci of his current research efforts are in the area of immunometabolism, that is the role of immune system in the regulation of metabolism.
- BA, University of Dublin, 1986
- PhD, Vanderbilt University, 1995
- Postdoctoral Fellow, Diabetes/Obesity, University of Texas, Southwestern Medical Center, 1998
Education & Training
Thapa, D., Wu, K., Stoner, M. W., Xie, B., Zhang, M., Manning, J. R., Lu, Z., Li, J. H., Chen, Y., Gucek, M., Playford, M. P., Mehta, N. N., Harmon, D., O'Doherty, R. M., Jurczak, M. J., Sack, M. N., Scott, I. The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial ß-oxidation enzyme HADHA. J Biol Chem. 2018; Epub ahead of print.
Bhatt, B. A., Dedousis, N., Sipula, I. J., O'Doherty, R. M. Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF-?B p50 null mice to obesity. Physiol Rep. 2018; 6(18): e13836.
Harmon, D. B., Wu, C., Dedousis, N., Sipula, I. J., Stefanovic-Racic, M., Schoiswohl, G., O'Donnell, C. P., Alonso, L. C., Kershaw, E. E., Kelley, E. E., O'Doherty, R. M. Adipose Tissue Derived Free Fatty Acids Initiate Myeloid Cell Accumulation in Mouse Liver in States of Lipid Oversupply. Am J Physiol Endocrinol Metab. 2018; Epub ahead of print.
van der Windt, D. J., Sud, V., Zhang, H., Varley, P. R., Goswami, J., Yazdani, H. O., Tohme, S., Loughran, P., O'Doherty, R. M., Minervini, M. I., Huang, H., Simmons, R. L., Tsung, A. Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in non-alcoholic steatohepatitis. Hepatology. 2018; Epub ahead of print.
Chartoumpekis, D. V., Yagishita, Y., Fazzari, M., Palliyaguru, D. L., Rao, U. N., Zaravinos, A., Khoo, N. K., Schopfer, F. J., Weiss, K. R., Michalopoulos, G. K., Sipula, I., O'Doherty, R. M., Kensler, T. W., Wakabyashi, N. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. JCI Insight. 2018; 3(5): pii:97735.
Chartoumpekis, D. V., Palliuaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K., Schopfer, F. J., Sipula, I., Yagishita, Y., Michaelopoulos, G. K., O'Doherty, R. M., Kensler, T. W. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2018; Epub ahead of print.
Liu, A., Chen, M., Kumar, R., Stefanovic-Racic, M., O'Doherty, R. M., Ding, Y., Jahnen-Dechent, W., Borghesi, L. Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nat Commun. 2018; 9(1): 708.
Thapa, D., Zhang, M., Manning, J. R., Guimaraes, D., Stoner, M., O'Doherty, R. M., Shiva, S., Scott, I. Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart. Am J Physiol Heart Circ Physiol. 2017; Epub ahead of print.
Zhang, P., Chu, T., Dedousis, N., Mantell, B. S., Sipula, I., Li, L., Bunce, K. D., Shaw, P. A., Katz, L. S., Zhu, J., Argmann, C., O'Doherty, R. M., Peters, D. G., Scott, D. K. DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet. Mol Metab. 2017; 6(4): 327-339.
Metlakunta, A., Huang, W., Sipula, I., Dedousis, N., Stefanovic-Racic, M., O'Doherty, R. M. Kupffer cells facilitate the acute effects of leptin on liver lipid metabolism. Am J Physiol Endocrinol Metab. 2017; 312(1): E11-E18.
- Editorial Board, American Journal of Physiology (Endo/Metabol), 2010-present
