Dr. Domsic's research interest centers around improving the care of patients with scleroderma. Her research to date has focused on creating and testing risk stratification strategies for scleroderma patients. These tools can be used to improve both patient care and clinical trial design. Her second main area of research interest is Raynaud's phenomenon and the vascular manifestations of scleroderma. Specifically she is interested in novel imaging techniques for vascular involvement in scleroderma and assessing new outcome measures for testing therapies treating Raynaud's phenomenon.
Dr. Domsic continues to be actively involved in several multi-center clinical trials investigating potential therapies for the management of scleroderma and Raynaud's phenomenon. She has current funding for an investigator-initiated trial examining the effect of atorvastatin on Raynaud's phenomenon that will be completed only at the University of Pittsburgh.
Dr. Domsic's primary clinical focus is the evaluation, management and care of patients with all types of scleroderma. She is the Clinical Director and sees patients in the Scleroderma Center, which is a multidisciplinary center dedicated to patient care and research of scleroderma. Dr. Domsic is also interested in the evaluation and management of patients with Raynaud phenomenon and mixed connective tissue disease.
Dr. Domsic and her colleagues in the Scleroderma Center participate in both investigator-initiated NIH and industry-sponsored clinical trials. They believe clinical trials are an important piece to offering advanced treatment options to patients.
- BS, University of Iowa, 1996
- MD, University of Iowa Carver College of Medicine, 2001
- MPH, University of Pittsburgh, 2008
- Internship, Duke University Medical Center, 2002
- Residency, Duke University Medical Center, 2004
- Fellowship, University of Pittsburgh Medical Center, 2006
Education & Training
Gourh, P., Remmers, E. F., Boyden, S. E., Alexander, T., Morgan, N. D., Shah, A. A., Mayes, M. D., Doumatey, A., Bentley, A. R., Shriner, D., Domsic, R. T., Medsger, T. A. Jr, et al. Whole-Exome Sequencing to Identify Rare Variants and Gene Networks that Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol. 2018
Pauling, J. D., Saketkoo, L. A., Domsic, R. T. Patient Perceptions of the Raynaud's Condition Score Diary Provide Insight Into Its Performance in Clinical Trials of Raynaud's Phenomenon: Comment on the Article by Denton et al. Arthritis Rheumatol. 2018; 70(6): 973-974.
Sand, J. M. B., Lamy, P., Juhl, P., Siebuhr, A. S., Iversen, L. V., Nawrocki, A., Larsen, M. R., Domsic, R. T., Franchimont, N., Chavez, J., Karsdal, M. A., Leeming, D. J. Development of a Neo-Epitope Specific Assay for Serological Assessment of Type VII Collagen Turnover and Its Relevance in Fibroproliferative Disorders. Assay Drug Dev Technol. 2018; 16(2): 123-131.
Shah, D. J., Hirpara, R., Poelman, C. L., Woods, A., Hummers, L. K., Wigley, F. M., Wright, J. L., Parekh, A., Steen, V. D., Domsic, R. T., Shah, A. A. Impact of Radiation Therapy on Scleroderma and Cancer Outcomes in Scleroderma Patients with Breast Cancer. Arthritis Care Res (Hoboken). 2018
Hsu, V. M., Denton, C. P., Domsic, R. T., Furst, D. E., Rischmueller, M., Stanislav, M., Steen, V. D., Distler, J. H. W., Korish, S., Cooper, A., Choi, S., Schafer, P. H., Horan, G., Hough, D. R. Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Rheumatol. 2018; 45(3): 405-410.
Pauling, J. D., Domsic, R. T., Saketkoo, L. A., Almeida, C., Withey, J., Jay, H., Frech, T. M., Ingegnoli, F., Dures, E., Robson, J., McHugh, N. J., Herrick, A. L., Matucci-Cerinic, M., Khanna, D., Hewlett, S. A multi-national qualitative research study exploring the patient experience of Raynaud's phenomenon in systemic sclerosis. Arthritis Care Res (Hoboken). 2017
Morgan, N. D., Shah, A. A., Mayes, M. D., Domsic, R. T., Medsger, T. A. Jr., Steen, V. D., Varga, J., Carns, M., Ramos, P. S., Silver, R. M., et al. Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. Medicine (Baltimore). 2017; 96(51): e8980.
Pauling, J. D., Frech, T. M., Domsic, R. T., Hudson, M. Patient participation in patient-reported outcome instrument development in systemic sclerosis. Clin Exp Rheumatol. 2017; 106(4): 182-192.
Gordon, J. K., Girish, G., Berrocal, V. J., Zhang, M., Hatzis, C., Assassi, S., Bernstein, E. J., Domsic, R. T., Hant, F. N., Hinchcliff, M., Schiopu, E., Steen, V. D., Frech, T. M., Khanna, D. Reliability and Validity of the Tender and Swollen Joint Counts and the Modified Rodnan Skin Score in Early Diffuse Cutaneous Systemic Sclerosis: Analysis from the Prospective Registry of Early Systemic Sclerosis Cohort. J Rheumatol. 2017; 44(6): 791-794.
Li, G., Larregina, A. T., Domsic, R. T., Stolz, D. B., Medsger, T. A. Jr., Lafyatis, R., Fuschiotti, P. Skin-Resident Effector Memory CD8+CD28- T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis. J Invest Dermatol. 2017; 137(5): 1042-1050.
