Samir Saba, MD

  • Professor of Medicine
  • Chief, Cardiology
  • Co-Director, UPMC Heart and Vascular Institute
  • Harry S. Tack Chair, School of Medicine
  • Professor in Clinical and Translational Science
Academic Interests

Dr. Saba has authored more than 250 manuscripts that were published in peer-reviewed journals and has been issued 3 patents for inventions in the field of cardiac electrophysiology. Dr. Saba is the recipient of research grants from the National Institutes of Health, the American Heart Association, the American Heart Foundation, and the American College of Cardiology. His research interests include:
1) Cardiac device therapy for heart failure
2) Post-MI cardiac monitoring
3) Tranlational research on the mechanism and therapies of ventricular arrhythmias

Dr. Saba’s clinical interest and expertise have focused on the management of arrhythmias and conduction abnormalities of the heart. He has wide experience in implanting and managing all cardiac implantable electronic devices (CIED), including pacemakers, defibrillators, and cardiac resynchronization therapy devices. He also has expertise in ablation procedures of ventricular and supraventricular arrhythmias including atrial fibrillation and ischemic ventricular tachycardia. In addition, Dr. Saba is nationally recognized for his expertise in CIED lead management, including lead extractions.

    Education & Training

  • BE, Electrical Engineering, American University of Beirut, 1989
  • MD, American University of Beirut, 1993
  • Residency in Internal Medicine, Tufts University - New England Medical Center, 1996
  • Cardiovascular Diseases, Tufts University - New England Medical Center, 1999
  • Cardiac Electrophysiology, Tufts University - New England Medical Center, 2000
Recent Publications

Voigt, A., Ezzeddine, R., Barrington, W., Obiaha-Ngwu, O., Ganz, L.I., London, B., Saba, S. Utilization of Implantable Cardioverter-Defibrillators in Survivors of Cardiac Arrest in the United States from 1996 to 2001. J Am Coll Cardiol. 2004; 44: 855-858.

Triola, B., Olson, M.B., Reis, S.E., Rautaharju, P., Bairey Merz, C.N., Kelsey, S.F., Shaw, L.J., Sharaf, B.L., Sopko, G., Saba, S. Electrocardiographic Predictors of Cardiovascular Outcome in Women: The NHLBI-Sponsored WISE Study. JACC. 2005; 46: 51-56.

Saba, S., Volosin, K., Yee, R., Swerdlow, C., Brown, M. Combined Atrial and Ventricular Anti-Tachycardia Pacing As a Novel Method of Rhythm Discrimination: The Dynamic Discrimination Download Study. Circulation. 2010; 121: 487-497.

Saba, S., Mehdi, H., Mathier, M., Islam, Z., Salama, G., London, B. Effect of right ventricular versus biventricular pacing on electrical remodeling in the normal heart. Circulation Arrhythmia and Electrophysiol. 2010; 3: 79-87.

Liu, J., Rattan, R., Adelstein, E., Barrington, W., Bazaz, R., Brode, S., Jain, S., Mendenhall, G.S., Nemec, J., Razak, E., Shalaby, A., Schwartzman, D., Voigt, A., Wang, N.C., Saba, S. Fluoroscopic Screening of Asymptomatic Patients with the Recalled Riata Lead Family. Circulation Arrhythmia and Electrophysiology. 2012; 5: 809-814.

Saba, S., Marek, J., Schwartzman, D., Jain, S., Adelstein, E., White, P., Oyenuga, O.A., Onishi, T., Soman, P., Gorcsan III, J. Echocardiography-Guided Left Ventricular Lead Placement for Cardiac Resynchronization Therapy: Results of the Speckle Tracking Assisted Resynchronization Therapy for Electrode Region (STARTER) Trial. Circulation Heart Failure. 2013; 6: 427-434.

Voigt, A., Shalaby, A., Saba, S. Rising Rates of Cardiac Rhythm Management Device Infections in the United States: 1996 through 2003. JACC. 2006; 48: 590-591.

Saba, S., Janczewski, A.M., Baker, L.C., Shusterman, V., Gursoy, E.C., Salama, G., McTiernan, C., London, B. Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of Tumor Necrosis Factor-alpha. Am J Physiol. 2005; 289: H1456-1467.

Saba, S., Mathier, M., Mehdi, H., Gursoy, E., Liu, T., Choi, B.R., Salama, G., London, B. Prevention of Adverse Electrical and Mechanical Remodeling with Bi-Ventricular Pacing in a Rabbit Model of Myocardial Infarction. Heart Rhythm J. 2008; 5: 124-130.
Khodanji, A., Maillart, L., Prokopyev, O.A., Roberts, M.S., Saba, S. Dynamic Abandon/Extract Decisions for Failed Cardiac Leads. Management Science. 2016; in press

    Honors and Awards
  • Editorial Board - Circulation, 2016-present
  • Editorial Board - Heart Rhythm Journal, 2014-present
  • Senior Editorial Consultant - Circulation Arrhythmia and Electrophysiology, 2019-present
  • Inventor on 4 patents
  • Best Doctors Pittsburgh Magazine
  • Edward I. Curtis Memorial Teaching Award, 2006
  • Pitt Innovation Award, 2011
Research Grants

Title: Arrhythmia Detection After Myocardial Infarction (AIDMI) trial
Role: Principal Investigator
Funding Agency: Abbott Laboratories
Grant Number: DRUG PROTOCOL 20453
Start Year: 2021
End Year: 2026