The Monga lab is focused on understanding the molecular and cellular basis of normal liver characteristics such as development, regeneration, metabolism and growth as well as liver pathologies such as neoplasms (HCC and hepatoblastoma), fibrosis, cirrhosis, alcoholic liver disease, non-alcoholic fatty liver disease, and others. This research focus incorporates studies on cell proliferation, adhesion, differentiation, invasion, apoptosis, metabolism, and on stem cells in adult, fetal, and embryonic livers.
- MD, Dayanand Medical College & Hospital, University, Chandigarh, India, 1992
- FSc, MM Modi College, Patiala, Punjab, India, 1988
Education & Training
Adebayo Michael AO, Ko S, Tao J, Moghe A, Yang H, Xu M, Russell JO, Pradhan-Sundd T, Liu S, Singh, Poddar M, Monga JS, Liu P, Oertel M, Ranganathan S, Singhi A, Rebouissou S, Zucman-Rossi J, Ribback S, Calvisi D, Qvartskhava N, Gorg B, Haussinger D, Chen X, Monga SP. Wnt-ß-catenin-GS-glutamine-mTORC1 axis in metabolic zonation and ß-catenin-mutated liver tumors offers novel therapeutic opportunities. Cell Metabolism. 2019
Monga SP. Liver regeneration in 2018. Updates on hepatic homeostasis and the many tiers of hepatobiliary repair. Nat Rev Gastroenterol Hepatol. 2018
Russell JO, Monga SP. Wnt/ß-catenin signaling in liver pathobiology. Annu Rev Pathol. 2018
Prexiosi M, Okabe H, Poddar M, Singh S, Monga SP. Endothelial Wnts regulate ß-catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt-Wnt situation. Hepatol Commun, e-collection, PubMed. 2018
Preziosi ME, Monga SP. Update on the Mechanisms of Liver Regeneration. Semin Liver Dis. 2017; 37(2): 141-151.
Monga SP. ß-Catenin signaling and roles in liver homeostasis, injury and tumorigenesis. Gastroenterology. 2015; 148 (7): 1294-1310.
Russell JO, Lu WY, Okabe H, Abrams M, Oertel M, Poddar M, Singh S, Forbes SJ, Monga SP. Hepatocyte-specific ß-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes. Hepatology. 2018
Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell JM, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2017
Kikuchi A, Pradhan-Sundd T, Singh S, Nagarajan S, Loizos N, Monga SP. Platelet-Derived Growth Factor Receptor ? Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017
Tao J, Zhang R, Singh S, Poddar M, Xu E, Oertel M, Chen X, Ganesh S, Abrams M, Monga SP. Targeting ß-catenin in hepatocellular cancers induced by co-expression of mutant ß-catenin and K-Ras in mice. Hepatology. 2016
- Elected to American Society for Clinical Investigations (ASCI), 2009
- Endowed Chair for Experimental Pathology, University of Pittsburgh, 2012
- Winner of the Outstanding Investigator Award, ASIP (2014), 2013
- Editor-in-Chief, Gene Expression: The Journal of Basic Liver Research (Cognizant Communication), 2015-present
- Recipient of the Robert E. Stowell Lectureship, UC Davis, Department of Pathology, 2016
- Fellow of American Association for the Study of the Liver Diseases (FAASLD), 2016
- Secretary Treasurer, American Society of Investigative Pathology, 2016
- Dr. Michael Gerber Memorial Lecture, Tulane University, New Orleans, LO, 2017
- Dr. Rao Memorial Award Lecture, Northwestern University, Chicago IL, 2018
- Takeda Distinguished Research Award, American Physiology Society, 2019
