Dr. Sheng’s research focuses on structure-function relationship and regulation of epithelial sodium channels. He and his colleagues continued the investigation of functional roles of individual subdomains within the extracellular regions of the sodium channels. His group also continued a study to characterize the genetic variants of human epithelial sodium channel genes and examine the roles of specific variants in blood pressure regulation using knock-in mouse models.
- MD, Binzhou Medical College, P.R. China, 1983
- MS, Shandong Medical University, P.R. China, 1986
- Post-doctoral Researcher, University of Pennsylvania School of Medicine, 1993
- Post-doctoral Researcher, University of Pennsylvania, 2000
Education & Training
Sheng, S., Maarouf, A.B., Bruns, J.B., Hughey, R.P., Kleyman, T.R. Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition. The Journal of biological chemistry. 2007; 282(28): 20180-90.
Maarouf, A.B., Sheng, N., Chen, J., Winarski, K.L., Okumura, S., Carattino, M.D., Boyd, C.R., Kleyman, T.R., Sheng, S. Novel determinants of epithelial sodium channel gating within extracellular thumb domains. The Journal of biological chemistry. 2009; 284(12): 7756-65.
Winarski, K.L., Sheng, N., Chen, J., Kleyman, T.R., Sheng, S. Extracellular allosteric regulatory subdomain within the gamma subunit of the epithelial Na+ channel. The Journal of biological chemistry. 2010; 285(35): 26088-96.
Shi, S., Ghosh, D.D., Okumura, S., Carattino, M.D., Kashlan, O.B, Sheng, S., Kleyman, T.R. Base of the thumb domain modulates epithelial sodium channel gating. The Journal of biological chemistry. 2011; 286(17): 14753-61.
Chen, J., Myerburg, M.M., Passero, C.J., Winarski, K.L., Sheng, S. External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains. The Journal of biological chemistry. 2011; 286(31): 27436-46.
Chen, J., Winarski, K.L., Myerburg, M.M., Pitt, B.R., Sheng,S. Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel. The Journal of biological chemistry. 2012; 287(42): 35589-98.
Chen, J., Kleyman, T.R., Sheng, S. Gain-of-function variant of the human epithelial sodium channel. American journal of physiology. 2013; 304(2): F207-13.
Warnock, D.G., Kusche-Vihrog, K., Tarjus, A., Sheng, S., Oberleithner, H., Kleyman, T.R., Jaisser, F. Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells. Nature reviews. Nephrology. 2014; 10(3): 146-57.
Chen, J., Kleyman, T.R., Sheng, S. Deletion of a-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module. American journal of physiology. Renal physiology. 2014; 306(5): F561-7.
Chen, J., Ray, E.C., Yates, M.E., Buck, T.M., Brodsky, J.L., Kinlough, C.L., Winarski, K.L., Hughey, R.P., Kleyman, T.R., Sheng, S. Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain. The Journal of Biological Chemistry. 2015; 290(41): 25140-50.
- Member, American Physiological Society, 2001-present
- Member, Biophysical Society, 2001-present
- Member, American Association for the Advancement of Science, 2002-present
- Member, American Society for Biochemistry and Molecular Biology, 2012-present
- Editorial Board Member, American Journal of Physiology - Renal Physiology, 2007-2016
- Editorial Board Member, Frontiers in Renal and Epithelial Physiology, 2010-present
