Dr. Kudryashova's lab research interests are focused on investigation of molecular and cellular mechanisms of pulmonary arterial hypertension (PAH), especially mechanisms of pulmonary vascular remodeling, clinically important and currently irreversible feature of PAH, with specific focus on the contribution of smooth muscle cells. Current research projects in the lab are focused on the studying impact of HIPK2, HIPPO-YAP/TAZ, and mTOR-Akt signaling pathways and their interactions on pathobiology of pulmonary vascular cells from patients with PAH and on identifying novel approaches to attenuate pulmonary vascular remodeling and overall pulmonary hypertension. Our long-standing research interests are also focused on studying the role of cell-cell interactions and extracellular matrix remodeling in development and progression of pulmonary vascular remodeling in PAH.
- MS, Biochemistry, Lomonosov Moscow State University, 2004
- PhD, Biochemistry, Lomonosov Moscow State University, 2011
- Postdoctoral Fellowship, University of Pennsylvania, 2013
- Postdoctoral Fellowship, University of Pittsburgh, 2014
Education & Training
R01 HL166932, HIPK2 signaling in Pulmonary Arterial Hypertension, PI, 2023-2028
