Dr. Corcoran’s primary research interests include aerosol drug delivery and aerosol-based nuclear imaging of the lung. He has been extensively involved in the development of inhaled medications for lung transplant recipients and cystic fibrosis patients and the development special techniques for improving inhaled drug delivery such as the use of low density gases and surfactants to improve drug distribution in the lungs. Dr. Corcoran had developed imaging techniques for quantifying pulmonary physiology including measurements of mucociliary clearance and liquid absorption in the airways. These techniques have been tested in a series of clinical studies involving adult and pediatric patients and will be used to screen new medications for treating lung diseases such as cystic fibrosis. Dr. Corcoran has been the Principal Investigator on several NIH RO1 and UO1 awards as well as grants from the Cystic Fibrosis Foundation and the U.S. Army. He has previously directed research funded by the U.S. Army and the Cystic Fibrosis Foundation.
- BS, Mechanical Engineering, Lehigh University, 1990
- MS, Mechanical Engineering, Lehigh University, 1992
- PhD, Bioengineering, Carnegie Mellon University, 2000
- Post-Doctoral Fellowship, Pulmonary and Critical Care Medicine, University of Pittsburgh School of Medicine, 2002
Education & Training
Corcoran TE, Saville A, Adams PS, Johnston DJ, Czachowski MR, Domnina YA, Li JH, Weiner DJ, Huber AS, Sanchez De Toledo J, Lo CW. Deposition Studies of Aerosol Delivery by Nasal Cannula to Infants. Pediatr Pulmonol. 2019; Aug;54(8): 1319-1325.
Serrano-Castillo F, Bertrand CA, Myerburg MM, Shapiro ME, Corcoran TE, Parker RS. A Physiologically-Motivated Model of Cystic Fibrosis Liquid and Solute Transport Dynamics across Primary Human Nasal Epithelia. J Pharmacokinet Pharmacodyn. 2019; PMID: 31494805
Corcoran TE, Huber AS, Myerburg MM, Weiner DJ, Locke LW, Lacy RT, Weber L, Czachowski MR, Johnston DJ, Muthukrishnan A, Lennox AT, Pilewski JM. Multi-probe nuclear imaging of the cystic fibrosis lung as a biomarker of therapeutic effect. J Aerosol Med Pulm Drug Deliv. 2019; Apr 10
Donaldson SH, Laube BL, Corcoran TE, Bhambhvani P, Zeman K, Ceppe A, Zeitlin PL, Mogayzel PJ Jr, Boyle M, Locke LW, Myerburg MM, Pilewski JM, Flanagan B, Rowe SM, Bennett WD. Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR. JCI Insight. 2018; Dec 20;3(24)
Locke LW, Myerburg MM, Weiner DJ, Markovetz MR, Parker RS, Muthukrishnan A, Weber L, Czachowski MR, Lacy RT, Pilewski JM, Corcoran TE. Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung. Eur Resp J. 2016; 47(5): 1392-401.
Stetten AZ, Moraca G, Corcoran TE, Tristam-Nagle S, Garoff S, Przybycien TM, Tilton RD. Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions. J Colloid Interface Sci. 2016; 484: 270-278.
Locke, LW, Myerburg, MM, Markovetz, MR, Parker, RS, Weber, L, Czachowski, MR, Harding, TJ, Brown, SL, Nero, JA, Pilewski, JM, Corcoran, TE. Quantitative Imaging of Airway Liquid Absorption in Cystic Fibrosis. Eur Resp J. 2014; 44(3): 675-84.
Iacono AT, Johnson BA, Grgurich WF, Youssef JG, Corcoran TE, Seiler DA, Dauber JH, Smaldon GC, Zeevi A, Yousem SA, Fung JJ, Burckart GJ, McCurry KR, Griffith BP. A Randomized Trial of Inhaled Cyclosporine in Lung Transplant Recipients. N Engl J Med. 2006; 354: 141-150.
- Young Investigator Award, International Society for Aerosols in Medicine, 2007
- Pitt Innovator Award, 2008
- Cathedral Award, Student Group Advising, University of Pittsburgh, 2009
- Cathedral Award, Student Group Advising, University of Pittsburgh, 2013
- Pitt Innovation Challenge Competition winner, 2014
- Pitt Greek Hall of Fame, 2016
