HIV/AIDS
-Viro-Immunological factors associated with HIV remission
-HIV drug resistance mutations
-Non-AIDS complications
Viral Hepatitis
-HIV/HBV co-infection
SARS-CoV-2
-Viro-Immunological factors associated with COVID-19 severity, SARS-CoV-2 RNAemia/Viremia, symptomatology
- Pre-Medical Education, Tsinghua University, 2010
- MD, Peking Union Medical College, 2015
- Residency, Internal Medicine, UPMC Presbyterian, 2019
- Fellowship, Infectious Diseases, Massachusetts General Hospital/Brigham and Women's Hospital Combined Program, 2021
Education & Training
Li Y*, Choudhary MC*, Regan J*, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. *, Equal Contribution. SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency. Science Translational Medicine. 2024; 16(731): eadk1599.
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Viral and host mediators of non-suppressible HIV-1 viremia. Nature Medicine. 2023; https://doi.org/10.1038/s41591-023-02611-1
Esmaeilzadeh E, Etemad B, Lavine CL, Garneau L, Li Y, Regan J, Wong C, Sharaf R, Connick E, Volberding P, Sagar M, Seaman MS, Li JZ. Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption. Science Translational Medicine. 2023; 15(695): eabq4490.
Etemad B*, Sun X*, Li Y*, Melberg M, Moisi D, Gottlieb R, Ahmed H, Aga E, Bosch RJ, Acosta EP, Yuki Y, Martin MP, Carrington M, Gandhi RT, Jacobson JM, Volberding P, Connick E, Mitsuyasu R, Frank I, Saag M, Eron JJ, Skiest D, Margolis DM, Havlir D, Schooley RT, Lederman MM, Yu XG, Li JZ. *, Equal Contribution. HIV post-treatment controllers have distinct immunological and virological features. Proceedings of the National Academy of Sciences of the United States of America. 2023; 120(11): e2218960120.
Chew KW, Moser C, Daar ES, Wohl DA, Li JZ, Coombs RW, Ritz J, Giganti M, Javan AC, Li Y, Choudhary MC, Deo R, Malvestutto C, Klekotka P, Price K, Nirula A, Fischer W, Bala V, Ribeiro RM, Perelson AS, Fletcher CV, Eron JJ, Currier JS; ACTIV-2/A5401 Study Team, Hughes MD, Smith DM. Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19. Nature Communications. 2022; 13(1): 4931.
Li Y, Harrison LJ, Chew KW, Currier JS, Wohl DA, Daar ES, Evering TH, Wu R, Giganti M, Ritz J, Javan AC, Coombs R, Moser C, Hughes MD, Eron JJ, Smith DM, Li JZ. Nasal and Plasma SARS-CoV-2 RNA Levels are Associated with Timing of Symptom Resolution in the ACTIV-2 Trial of Non-hospitalized Adults with COVID-19. Clinical Infectious Diseases. 2023
Boucau J, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Lipiner T, Kittilson A, Melberg M, Li Y, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Goldberg MB, Vyas JM, Li JZ, Lemieux JE, Siedner MJ, Barczak AK. Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection. New England Journal of Medicine. 2022; 387(3): 275-277.
Li Y. Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave. Journal of the American Medical Association. 2022; 327(21): 2147-2148.
Li Y, Schneider AM, Mehta A, Sade-Feldman M, Kays KR, Gentili M, Charland NC, Gonye AL, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Parry BA, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Regan J, Flynn JP, Villani AC, Hacohen N, Goldberg MB, Filbin MR, Li JZ. SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes. Journal of Clinical Investigation. 2021; 131(13): e148635.
Li Y, Etemad B, Dele-Oni R, Sharaf R, Gao C, Lichterfeld M, Li JZ. Drug resistance mutations in HIV provirus are associated with defective proviral genomes with hypermutation. AIDS. 2021; 35(7): 1015-1020.
- International Scholarship Award- IAS, 2015
- Young Investigator Scholarship- CROI, 2021/2019/2016
- Editorial Advisory Board of Open Forum Infectious Diseases, 2021-Present
- Edward H. Kass Award for Clinical Excellence in Infectious Diseases- Massachusetts Infectious Diseases Society, 2021
- Maxwell Finland Award for Excellence in Research- Massachusetts Infectious Diseases Society, 2022