Dr. Ikeda’s research interests focus on furthering the understanding of the various cellular mechanisms that regulate urinary bladder contractile and storage functions, as well as determining the consequences of neurogenic injury, chemical cystitis and ionizing radiation exposure to the lower urinary tract to elucidate novel therapeutic agents.
- BSc, Biochemistry, Imperial College London, University of London, 2001
- PhD, Urology/Cell Physiology, University College London, University of London, 2006
Education & Training
Ikeda Y, Zabbarova I, de Rijk M, Kanai A, Wolf-Johnston A, Weiss JP, Jackson E, Birder L. Effects of vasopressin receptor agonists on detrusor smooth muscle tone in young and aged bladders: Implications for nocturia treatment. Continence (Amst). 2022 Jun;2:100032. PMID: 35789681.
Ikeda Y, Zabbarova I, Tyagi P, Hitchens TK, Wolf-Johnston A, Wipf P, Kanai A. Targeting neurotrophin and nitric oxide signaling to treat spinal cord injury and associated neurogenic bladder overactivity. Continence (Amst). 2022 Mar;1:100014. PMID: 37207253.
McCarthy CJ, Marangos C, Fry CH, Ikeda Y. ATP transients accompany spontaneous contractions in isolated guinea-pig detrusor smooth muscle. Exp Physiol. 2019 Nov;104(11):1717-1725. PMID: 31464344.
Ikeda Y, Wolf-Johnston A, Roppolo JR, Buffington CAT, Birder L. Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin. Int Neurourol J. 2018 Dec;22(4):246-251. PMID: 30599495.
Ikeda Y, Zabbarova IV, Birder LA, Wipf P, Getchell SE, Tyagi P, Fry CH, Drake MJ, Kanai AJ. Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice. Neurourol Urodyn. 2018 Nov;37(8):2441-2451. PMID: 29806709.
Kanai A, Fry C, Hanna-Mitchell A, Birder L, Zabbarova I, Bijos D, Ikeda Y. Do we understand any more about bladder interstitial cells?-ICI-RS 2013. Neurourol Urodyn. 2014 Jun;33(5):573-6. PMID: 24838179.
Ikeda Y, Zabbarova IV, Birder LA, de Groat WC, McCarthy CJ, Hanna-Mitchell AT, Kanai AJ. Botulinum neurotoxin serotype A suppresses neurotransmitter release from afferent as well as efferent nerves in the urinary bladder. Eur Urol. 2012 Dec;62(6):1157-64. PMID: 22480459.
Ikeda Y, Birder L, Buffington C, Roppolo J, Kanai A. Mucosal muscarinic receptors enhance bladder activity in cats with feline interstitial cystitis. J Urol. 2009 Mar;181(3):1415-22. PMID: 19157447.
Ikeda Y, Fry C, Hayashi F, Stolz D, Griffiths D, Kanai A. Role of gap junctions in spontaneous activity of the rat bladder. Am J Physiol Renal Physiol. 2007 Oct;293(4):F1018-25. PMID: 17581924.
Kanai A, Roppolo J, Ikeda Y, Zabbarova I, Tai C, Birder L, Griffiths D, de Groat W, Fry C. Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists. Am J Physiol Renal Physiol. 2007 Mar;292(3):F1065-72. PMID: 17107944.
